Immunization against GnRF in adult cattle: a prospective field study.

Hirsbrunner, Gabriela; Rigert, Sarah; Janett, Fredi; Hüsler, Jürg; Schnydrig, Philipp; Lopez, Ester; Amatayakul-Chantler, Sue; Steiner, Adrian (2017). Immunization against GnRF in adult cattle: a prospective field study. BMC veterinary research, 13(1), p. 208. BioMed Central 10.1186/s12917-017-1129-x

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BACKGROUND

Suppression of cyclic activity in cattle is often desired in alpine farming and for feedlot cattle, not intended for breeding. A cattle specific anti-GnRF vaccine (Bopriva™) is registered for use in heifers and bulls in different countries. In adult cows vaccinated with Bopriva™, the median period until recurrence of class III follicles was 78 days from the day of the 2nd vaccination and reversibility could be proven, as out of 11 experimental cows 10 cows became pregnant at first, and one cow at second insemination. In the present study, 76 healthy, cyclic Eringer heifers and cows were vaccinated twice with Bopriva™ 3-7 weeks apart, to prevent estrus during alpine pasturing. Blood samples were taken for progesterone and GnRF antibody titer analysis on the day of inclusion (7-9 d before the first vaccination) and at the first vaccination. At the same time, gynaecological examinations were performed. When estrus occurred in the course of the alpine pasturing season, a gynaecological examination was done including analysis of a blood sample (progesterone, anti-GnRF antibody titer). Cows were followed for fertility out to 26 months post second vaccination.

RESULTS

Median duration of estrus suppression was 191 days after the second vaccination (when the 2 vaccinations were given 28-35 days apart). From n = 13 cows showing signs of estrus on the alpine pasture, n = 7 could not be confirmed in estrus (serum progesterone value >2 ng/ml, no class III follicles seen using ultrasonography). Median duration between second vaccination and next calving was 496 days (25%/75% quartiles: 478/532 days).

CONCLUSION

Bopriva™ induced a reliable and reversible suppression of estrus for more than 3 months in over 90% of the cows.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Research Foci > Veterinary Public Health / Herd Health Management
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV)
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Clinic for Ruminants
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Veterinary Bacteriology

UniBE Contributor:

Hirsbrunner, Gabriela, Schnydrig, Philipp, Steiner, Adrian

Subjects:

600 Technology > 630 Agriculture
600 Technology > 610 Medicine & health

ISSN:

1746-6148

Publisher:

BioMed Central

Language:

English

Submitter:

Jeannette Glauser

Date Deposited:

11 Oct 2017 16:11

Last Modified:

05 Dec 2022 15:06

Publisher DOI:

10.1186/s12917-017-1129-x

PubMed ID:

28666431

Uncontrolled Keywords:

Anti-GnRF Antibody titer Cattle Eringer breed Estrus GnRH Immunization

BORIS DOI:

10.7892/boris.101829

URI:

https://boris.unibe.ch/id/eprint/101829

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