Neurologic Clinical Signs in Cattle With Astrovirus-Associated Encephalitis.

Deiss, Ramona; Selimovic-Hamza, Senija; Seuberlich, Torsten; Meylan, Mireille (2017). Neurologic Clinical Signs in Cattle With Astrovirus-Associated Encephalitis. Journal of veterinary internal medicine, 31(4), pp. 1209-1214. Wiley-Blackwell 10.1111/jvim.14728

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BACKGROUND Evidence of neurotropic astroviruses has been established using novel genetic methods in cattle suffering from viral encephalitis of previously unknown origin. OBJECTIVES To describe the clinical signs observed in cattle with astrovirus-associated encephalitis. ANIMALS Eight cattle (4 cows, 3 heifers, and 1 bull of 4 different breeds) admitted to the Clinic for Ruminants for neurologic disease and 1 cow investigated in the field. METHODS Cases were selected based on neuropathologic diagnosis of nonsuppurative encephalitis, positive in situ hybridization result for astrovirus, and availability of the results of physical and neurologic evaluations. Laboratory results were evaluated if available. RESULTS The most frequently observed clinical signs were decreased awareness of surroundings (7), cranial nerve dysfunction (5), and recumbency (5). The cow seen in the field was the only animal that had severe behavioral changes. Cell counts in cerebrospinal fluid (CSF) were increased in 4 animals, and protein concentration was increased in 3 of 5 specimens. In 1 case, the presence of astrovirus could be identified in a CSF sample by reverse transcriptase polymerase chain reaction. Other laboratory abnormalities were nonspecific. CONCLUSIONS AND CLINICAL IMPORTANCE Astrovirus infection may be an important differential diagnosis in cattle with clinical signs of brain disease and should be considered after exclusion of other causes. The clinical and epidemiological relevance of encephalitis associated with astrovirus infection should be further investigated.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Research Foci > NeuroCenter
05 Veterinary Medicine > Research Foci > Veterinary Public Health / Herd Health Management
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV)
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Clinic for Ruminants
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Experimental Clinical Research
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH)

UniBE Contributor:

Deiss, Ramona; Selimovic-Hamza, Senija; Seuberlich, Torsten and Meylan, Mireille

Subjects:

600 Technology > 610 Medicine & health
600 Technology > 630 Agriculture

ISSN:

0891-6640

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Daniela Fasel

Date Deposited:

13 Oct 2017 16:10

Last Modified:

09 Nov 2018 08:49

Publisher DOI:

10.1111/jvim.14728

PubMed ID:

28544318

Uncontrolled Keywords:

Atypical Bovine Central nervous system Viral

BORIS DOI:

10.7892/boris.102065

URI:

https://boris.unibe.ch/id/eprint/102065

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