Correlating Interictal Spikes with Sigma and Delta Dynamics during Non-Rapid-Eye-Movement-Sleep.

Zubler, Frédéric; Rubino, Annalisa; Lo Russo, Giorgio; Schindler, Kaspar Anton; Nobili, Lino (2017). Correlating Interictal Spikes with Sigma and Delta Dynamics during Non-Rapid-Eye-Movement-Sleep. Frontiers in neurology, 8(288), p. 288. Frontiers Media S.A. 10.3389/fneur.2017.00288

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Interictal spikes (IS) are one of the major hallmarks of epilepsy. Understanding the factors promoting or suppressing IS would increase our comprehension of epilepsy and possibly open new avenues for therapy. Sleep strongly influences epileptic activity, and the modulatory effects of the different sleep stages on IS have been studied for decades. However, several aspects are still disputed, in particular the role of sleep spindles and slow waves in the activation of IS during Non-REM sleep. Here, we correlate the rate of IS with quantitative measures derived from stereo-EEG during one Non-REM cycle in 10 patients suffering from drug-resistant epilepsy due to type 2 focal cortical dysplasia. We show that the IS rate (ISR) is positively correlated with sigma power (a surrogate for sleep-spindle density) but negatively correlated with delta power (surrogate for slow wave activity). In addition, we present two new indices for quantifying the spatial and temporal instability of sleep. We found that both instability indices are correlated with a high ISR. The main contribution of this study is to confirm the suppressive effect of stable deep sleep on IS. This result might influence future guidelines for therapy of patients suffering from epilepsy and sleep disorders.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DCR Unit Sahli Building > Forschungsgruppe Neurologie
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Zubler, Frédéric; Schindler, Kaspar Anton and Nobili, Lino

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1664-2295

Publisher:

Frontiers Media S.A.

Language:

English

Submitter:

Stefanie Hetzenecker

Date Deposited:

12 Oct 2017 10:45

Last Modified:

15 Oct 2017 02:23

Publisher DOI:

10.3389/fneur.2017.00288

PubMed ID:

28690583

Uncontrolled Keywords:

epileptic spikes focal cortical dysplasia sigma power sleep sleep instability slow wave activity stereo-EEG

BORIS DOI:

10.7892/boris.102103

URI:

https://boris.unibe.ch/id/eprint/102103

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