Chan, Andrew; Cutter, Gary; Fox, Robert J; Xiao, James; Lewin, James B; Edwards, Michael R (2017). Comparative effectiveness of delayed-release dimethyl fumarate versus glatiramer acetate in multiple sclerosis patients: results of a matching-adjusted indirect comparison. Journal of comparative effectiveness research, 6(4), pp. 313-323. Future Medicine 10.2217/cer-2016-0085
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AIM
Using matching-adjusted indirect comparison, we compared efficacy outcomes in patients with relapsing-remitting multiple sclerosis treated with delayed-release dimethyl fumarate (DMF) or glatiramer acetate (GA).
MATERIALS & METHODS
An indirect comparison of DMF (patient-level data) and GA (aggregate data) was conducted, with average baseline characteristics of DMF patients weighted to match those for GA patients. Direct comparison of DMF and GA was conducted in CONFIRM. Final results pooled the indirect and direct comparisons using meta-analysis.
RESULTS
After matching, baseline characteristics were balanced between DMF and GA patients. Compared with GA, efficacy was significantly in favor of DMF as measured by annualized relapse rate (rate ratio: 0.76; 95% CI: 0.57-1.00; p = 0.0474) and 12-week confirmed disability progression (risk ratio: 0.59; 95% CI: 0.46-0.76; p < 0.0001).
CONCLUSION
DMF demonstrated superior clinical efficacy versus GA.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DCR Unit Sahli Building > Forschungsgruppe Neurologie 04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology |
UniBE Contributor: |
Chan, Andrew Hao-Kuang |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2042-6313 |
Publisher: |
Future Medicine |
Language: |
English |
Submitter: |
Stefanie Hetzenecker |
Date Deposited: |
24 Oct 2017 10:14 |
Last Modified: |
02 Mar 2023 23:29 |
Publisher DOI: |
10.2217/cer-2016-0085 |
PubMed ID: |
28350241 |
Uncontrolled Keywords: |
comparative effectiveness delayed-release dimethyl fumarate glatiramer acetate multiple sclerosis |
BORIS DOI: |
10.7892/boris.102106 |
URI: |
https://boris.unibe.ch/id/eprint/102106 |
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