Comparative effectiveness of delayed-release dimethyl fumarate versus glatiramer acetate in multiple sclerosis patients: results of a matching-adjusted indirect comparison.

Chan, Andrew; Cutter, Gary; Fox, Robert J; Xiao, James; Lewin, James B; Edwards, Michael R (2017). Comparative effectiveness of delayed-release dimethyl fumarate versus glatiramer acetate in multiple sclerosis patients: results of a matching-adjusted indirect comparison. Journal of comparative effectiveness research, 6(4), pp. 313-323. Future Medicine 10.2217/cer-2016-0085

[img]
Preview
Text
cer-2016-0085.pdf - Published Version
Available under License Creative Commons: Attribution-Noncommercial-No Derivative Works (CC-BY-NC-ND).

Download (2MB) | Preview

AIM Using matching-adjusted indirect comparison, we compared efficacy outcomes in patients with relapsing-remitting multiple sclerosis treated with delayed-release dimethyl fumarate (DMF) or glatiramer acetate (GA). MATERIALS & METHODS An indirect comparison of DMF (patient-level data) and GA (aggregate data) was conducted, with average baseline characteristics of DMF patients weighted to match those for GA patients. Direct comparison of DMF and GA was conducted in CONFIRM. Final results pooled the indirect and direct comparisons using meta-analysis. RESULTS After matching, baseline characteristics were balanced between DMF and GA patients. Compared with GA, efficacy was significantly in favor of DMF as measured by annualized relapse rate (rate ratio: 0.76; 95% CI: 0.57-1.00; p = 0.0474) and 12-week confirmed disability progression (risk ratio: 0.59; 95% CI: 0.46-0.76; p < 0.0001). CONCLUSION DMF demonstrated superior clinical efficacy versus GA.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DCR Unit Sahli Building > Forschungsgruppe Neurologie
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Chan, Andrew

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2042-6313

Publisher:

Future Medicine

Language:

English

Submitter:

Stefanie Hetzenecker

Date Deposited:

24 Oct 2017 10:14

Last Modified:

24 Oct 2017 10:20

Publisher DOI:

10.2217/cer-2016-0085

PubMed ID:

28350241

Uncontrolled Keywords:

comparative effectiveness delayed-release dimethyl fumarate glatiramer acetate multiple sclerosis

BORIS DOI:

10.7892/boris.102106

URI:

https://boris.unibe.ch/id/eprint/102106

Actions (login required)

Edit item Edit item
Provide Feedback