Depression is Associated with Increased Risk for Metabolic Syndrome in Latinos with Type 2 Diabetes.

Cardenas, Veronica; Mausbach, Brent T; Sommerfeld, David; Jimenez, Daniel; von Känel, Roland; Ho, Jennifer S; Garcia, Piedad; Aarons, Gregory A (2017). Depression is Associated with Increased Risk for Metabolic Syndrome in Latinos with Type 2 Diabetes. American journal of geriatric psychiatry, 25(6), pp. 646-653. Elsevier 10.1016/j.jagp.2017.02.017

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OBJECTIVE Latino adults are 66% more likely to have diabetes relative to non-Latino white adults. Prior research identifies depression as a significant risk factor for metabolic syndrome (MetS), but research examining this among Latinos is lacking. This study sought to examine the links between depression and MetS and clinically significant elevations in cardiovascular disease risk markers of MetS in a sample of community-dwelling older Latinos with type 2 diabetes. METHODS Participants were 332 community-dwelling older (≥60 years) Latinos with type 2 diabetes who completed the nine-item Patient Health Questionnaire and received a health checkup assessing body mass index (BMI), triglyceride and high-density lipoprotein (HDL) cholesterol levels, and blood pressure. Logistic regression analysis compared MetS rates of those meeting criteria for depression with those who did not. Secondary analyses examined the associations between depression and individual MetS components. All analyses controlled for demographic (e.g., income, age) and other potential MetS risk factors (e.g., smoking status, physical activity, alcohol level consumption). RESULTS Depression was significantly associated with an increased risk of MetS (OR: 5.79; 95% CI: 1.32-25.42) and clinically significant elevations in triglycerides (OR: 2.71; 95% CI: 1.15-6.42) and reduced (HDL) cholesterol (OR: 2.46; 95% CI: 1.11-5.45). A significant association was not observed between depression and either BMI or hypertension. CONCLUSION Depression is significantly linked to MetS, and most notably dyslipidemia, in older Latinos with diabetes. Causation, however, cannot be inferred from these analyses given the cross-sectional nature of the study. Future research should prospectively examine the directionality of this effect.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DCR Unit Sahli Building > Forschungsgruppe Neurologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Mu50 > Forschungsgruppe Psychosomatik

UniBE Contributor:

von Känel, Roland

ISSN:

1064-7481

Publisher:

Elsevier

Language:

English

Submitter:

Stefanie Hetzenecker

Date Deposited:

23 Oct 2017 10:05

Last Modified:

23 Oct 2017 10:05

Publisher DOI:

10.1016/j.jagp.2017.02.017

PubMed ID:

28341138

Uncontrolled Keywords:

Latino cardiovascular disease risk depression diabetes metabolic syndrome

URI:

https://boris.unibe.ch/id/eprint/102126

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