Adaptive Deep Brain Stimulation for Movement Disorders: The Long Road to Clinical Therapy.

Meidahl, Anders Christian; Tinkhauser, Gerd; Herz, Damian Marc; Cagnan, Hayriye; Debarros, Jean; Brown, Peter (2017). Adaptive Deep Brain Stimulation for Movement Disorders: The Long Road to Clinical Therapy. Movement disorders, 32(6), pp. 810-819. Wiley-Blackwell 10.1002/mds.27022

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Continuous high-frequency DBS is an established treatment for essential tremor and Parkinson's disease. Current developments focus on trying to widen the therapeutic window of DBS. Adaptive DBS (aDBS), where stimulation is dynamically controlled by feedback from biomarkers of pathological brain circuit activity, is one such development. Relevant biomarkers may be central, such as local field potential activity, or peripheral, such as inertial tremor data. Moreover, stimulation may be directed by the amplitude or the phase (timing) of the biomarker signal. In this review, we evaluate existing aDBS studies as proof-of-principle, discuss their limitations, most of which stem from their acute nature, and propose what is needed to take aDBS into a chronic setting. © 2017 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Tinkhauser, Gerd

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0885-3185

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Stefanie Hetzenecker

Date Deposited:

23 Oct 2017 16:17

Last Modified:

27 Oct 2019 21:06

Publisher DOI:

10.1002/mds.27022

PubMed ID:

28597557

Uncontrolled Keywords:

Parkinson's disease brain-computer interface closed-loop deep brain stimulation essential tremor

BORIS DOI:

10.7892/boris.102231

URI:

https://boris.unibe.ch/id/eprint/102231

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