Schenk, Mirjam; Fabri, Mario; Krutzik, Stephan R; Lee, Delphine J; Vu, David M; Sieling, Peter A; Montoya, Dennis; Liu, Philip T; Modlin, Robert L (2014). Interleukin-1β triggers the differentiation of macrophages with enhanced capacity to present mycobacterial antigen to T cells. Immunology, 141(2), pp. 174-180. Wiley-Blackwell 10.1111/imm.12167
Full text not available from this repository. (Request a copy)The rapid differentiation of monocytes into macrophages (MΦ) and dendritic cells is a pivotal aspect of the innate immune response. Differentiation is triggered following recognition of microbial ligands that activate pattern recognition receptors or directly by pro-inflammatory cytokines. We demonstrate that interleukin-1β (IL-1β) induces the rapid differentiation of monocytes into CD209(+) MΦ, similar to activation via Toll-like receptor 2/1, but with distinct phenotypic and functional characteristics. The IL-1β induced MΦ express higher levels of key markers of phagocytosis, including the Fc-receptors CD16 and CD64, as well as CD36, CD163 and CD206. In addition, IL-1β-induced MΦ exert potent phagocytic activity towards inert particles, oxidized low-density lipoprotein and mycobacteria. Furthermore, IL-1β-induced MΦ express higher levels of HLA-DR and effectively present mycobacterial antigens to T cells. Therefore, the ability of IL-1β to induce monocyte differentiation into MΦ with both phagocytosis and antigen-presenting function is a distinct part of the innate immune response in host defence against microbial infection.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Service Sector > Institute of Pathology > Immunopathology |
UniBE Contributor: |
Schenk, Mirjam |
ISSN: |
0019-2805 |
Publisher: |
Wiley-Blackwell |
Language: |
English |
Submitter: |
Mirjam Schenk |
Date Deposited: |
25 Jul 2017 15:33 |
Last Modified: |
05 Dec 2022 15:06 |
Publisher DOI: |
10.1111/imm.12167 |
PubMed ID: |
24032597 |
Uncontrolled Keywords: |
antigen presentation; infection; innate immunity; macrophages/monocytes; mycobacteria/Mycobacterium |
URI: |
https://boris.unibe.ch/id/eprint/102298 |
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