Endoluminal laser-assisted vascular anastomosis-an in vivo study in a pig model

Mbaidjol, Zacharia; Kiermeir, David; Schönfeld, Annemarie; Arnoldi, Jörg; Frenz, Martin; Constantinescu, Mihai Adrian (2017). Endoluminal laser-assisted vascular anastomosis-an in vivo study in a pig model. Lasers in medical science, 32(6), pp. 1343-1348. Springer 10.1007/s10103-017-2250-6

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Microvascular surgery is time consuming and requires high expertise. Laser-assisted vascular anastomosis (LAVA) is a promising sutureless technique that has the potential to facilitate this procedure. In this study, we evaluate the handling of our soldering material and the 1-week patency rate in a porcine model. Six pigs were subjected to LAVA. For each pig, the saphenous artery on one side was transected while the contralateral side was used as control. A porous polycaprolactone scaffold soaked in 40% (w/w) bovine serum albumin solution in combination with 0.1% (w/w) indocyanine green was wrapped at the anastomosis site and at the control site. Both sides were then soldered with a diode laser coupled into a light diffuser fiber emitting radiation with a wavelength of 808 nm and a power of 2-2.2 W. Vessels were successfully soldered with a 100% immediate patency rate. The 1-week patency rate was 83% for the anastomoses versus 67% for the control side. Vessels irradiated for 80 to 90 s tended to maintain the highest patency rate. Macroscopically, there was no difference between the two sides. The patch was easy to handle provided that the environment could be kept dry. This study shows the potential and the limitations of endoluminal LAVA as a one-step procedure without the use of stay sutures. Further studies are needed to improve the soldering material, the long-term patency rate, and standardized irradiation parameters. The long-term effects of laser soldering on the vessel wall remain to be determined.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Orthopaedic, Plastic and Hand Surgery (DOPH) > Clinic of Plastic and Hand Surgery
04 Faculty of Medicine > Department of Orthopaedic, Plastic and Hand Surgery (DOPH) > Clinic of Plastic and Hand Surgery > Plastic, Reconstructive and Aesthetic Surgery
08 Faculty of Science > Institute of Applied Physics
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Mu50 > Forschungsgruppe Handchirurgie

UniBE Contributor:

Kiermeir, David; Schönfeld, Annemarie; Arnoldi, Jörg; Frenz, Martin and Constantinescu, Mihai Adrian

Subjects:

600 Technology > 610 Medicine & health
600 Technology > 620 Engineering

ISSN:

0268-8921

Publisher:

Springer

Language:

English

Submitter:

Veronika Picha

Date Deposited:

13 Sep 2017 08:20

Last Modified:

13 Sep 2017 08:20

Publisher DOI:

10.1007/s10103-017-2250-6

PubMed ID:

28608190

Uncontrolled Keywords:

LAVA Soldering Sutureless anastomoses

BORIS DOI:

10.7892/boris.102329

URI:

https://boris.unibe.ch/id/eprint/102329

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