Albanese, Emiliano; Launer, Lenore J.; Egger, Matthias; Prince, Martin J.; Giannakopoulos, Panteleimon; Wolters, Frank J.; Egan, Kieren (2017). Body mass index in midlife and dementia: Systematic review and meta-regression analysis of 589,649 men and women followed in longitudinal studies. Alzheimer's & dementia, 8(C), pp. 165-178. Elsevier 10.1016/j.dadm.2017.05.007
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Introduction
We conducted a meta-analysis of the conflicting epidemiologic evidence on the association between midlife body mass index (BMI) and dementia.
Methods
We searched standard databases to identify prospective, population-based studies of dementia risk by midlife underweight, overweight, and obesity. We performed random-effects meta-analyses and meta-regressions of adjusted relative risk (RR) estimates and formally explored between-study heterogeneity.
Results
We included 19 studies on 589,649 participants (2040 incident dementia cases) followed up for up to 42 years. Midlife (age 35 to 65 years) obesity (BMI ≥ 30) (RR, 1.33; 95% confidence interval [CI], 1.08–1.63), but not overweight (25 < BMI < 30) (RR, 1.07; 95% CI, 0.96–1.20), was associated with dementia in late life. The association with midlife underweight (RR, 1.39; 95% CI, 1.13–1.70) was potentially driven by residual confounding (P from meta-regression = .004), selection (P = .046), and information bias (P = .007).
Discussion
Obesity in midlife increases the risk of dementia. The association between underweight and dementia remains controversial.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM) |
UniBE Contributor: |
Egger, Matthias |
Subjects: |
600 Technology > 610 Medicine & health 300 Social sciences, sociology & anthropology > 360 Social problems & social services |
ISSN: |
1552-5279 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Beatrice Minder Wyssmann |
Date Deposited: |
05 Sep 2017 10:25 |
Last Modified: |
05 Dec 2022 15:06 |
Publisher DOI: |
10.1016/j.dadm.2017.05.007 |
Uncontrolled Keywords: |
Dementia; Body mass index; BMI; Obesity; Meta-analysis |
BORIS DOI: |
10.7892/boris.102396 |
URI: |
https://boris.unibe.ch/id/eprint/102396 |
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