Vicari, Alain P; Schoepfer, Alain M; Meresse, Bertrand; Goffin, Laurence; Léger, Olivier; Josserand, Soheila; Guégan, Nicolas; Yousefi, Shida; Straumann, Alex; Cerf-Bensussan, Nadine; Simon, Hans-Uwe; Chvatchko, Yolande (2017). Discovery and characterization of a novel humanized anti-IL-15 antibody and its relevance for the treatment of refractory celiac disease and eosinophilic esophagitis. mAbs, 9(6), pp. 927-944. Taylor & Francis 10.1080/19420862.2017.1332553
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Simon_discovery and characterization of a novel humanized_2017-IL-15 paper.pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Download (1MB) |
Interleukin-15 (IL-15) is a critical regulator of immune responses, especially at mucosal interfaces within the gastro-intestinal tract. Here, we describe the discovery and characterization of a humanized antibody to IL-15. Data from its epitope and mode of action, cell biology and primate pharmacology, as well as translational studies in human samples and in vivo proof-of-concept experiments in mouse models demonstrate the therapeutic potential of this new antibody targeting IL-15 for refractory celiac disease and eosinophilic esophagitis.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology |
UniBE Contributor: |
Yousefi, Shida, Simon, Hans-Uwe |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1942-0870 |
Publisher: |
Taylor & Francis |
Language: |
English |
Submitter: |
Jana Berger |
Date Deposited: |
20 Oct 2017 09:26 |
Last Modified: |
05 Dec 2022 15:06 |
Publisher DOI: |
10.1080/19420862.2017.1332553 |
PubMed ID: |
28581883 |
Uncontrolled Keywords: |
Antibody IL-15 celiac disease cis eosinophilic esophagitis humanized interleukin-15 trans |
BORIS DOI: |
10.7892/boris.102421 |
URI: |
https://boris.unibe.ch/id/eprint/102421 |
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