Small-animal PET/CT for monitoring the development and response to chemotherapy of thymic lymphoma in Trp53-/- mice

Walter, Martin A; Hildebrandt, Isabel J; Hacke, Katrin; Kesner, Adam L; Kelly, Owen; Lawson, Gregory W; Phelps, Michael E; Czernin, Johannes; Weber, Wolfgang A; Schiestl, Robert H (2010). Small-animal PET/CT for monitoring the development and response to chemotherapy of thymic lymphoma in Trp53-/- mice. Journal of nuclear medicine, 51(8), pp. 1285-92. New York, N.Y.: Society of Nuclear Medicine 10.2967/jnumed.109.073585

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Transgenic mouse models of human cancers represent one of the most promising approaches to elucidate clinically relevant mechanisms of action and provide insights into the treatment efficacy of new antitumor drugs. The use of Trp53 transgenic mice (Trp53 knockout [Trp53(-/-)] mice) for these kinds of studies is, so far, restricted by limitations in detecting developing tumors and the lack of noninvasive tools for monitoring tumor growth, progression, and treatment response.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Clinic of Nuclear Medicine

UniBE Contributor:

Walter, Martin Alexander

ISSN:

0161-5505

Publisher:

Society of Nuclear Medicine

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:09

Last Modified:

17 Mar 2015 19:10

Publisher DOI:

10.2967/jnumed.109.073585

PubMed ID:

20660381

Web of Science ID:

000280645600027

URI:

https://boris.unibe.ch/id/eprint/1029 (FactScience: 201709)

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