Mueller, Beatrice U; Pabst, Thomas (2010). Lineage-specific transcription factor aberrations in AML. Cancer treatment and research, 145, pp. 109-125. New York, N.Y.: Springer Science+Business Media
Full text not available from this repository.Transcription factors play a key role in the commitment of hematopoietic stem cells to differentiate into specific lineages [78]. This is particularly important in that a block in terminal differentiation is the key contributing factor in acute leukemias. This general theme of the role of transcription factors in differentiation may also extend to other tissues, both in terms of normal development and cancer. Consistent with the role of transcription factors in hematopoietic lineage commitment is the frequent finding of aberrations in transcription factors in AML patients. Here, we intend to review recent findings on aberrations in lineage-restricted transcription factors as observed in patients with acute myeloid leukemia (AML).
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine > Centre of Competence for General Internal Medicine 04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology |
UniBE Contributor: |
Müller, Beatrice Ursula, Pabst, Thomas Niklaus |
ISSN: |
0927-3042 |
Publisher: |
Springer Science+Business Media |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:07 |
Last Modified: |
02 Mar 2023 23:20 |
PubMed ID: |
20306248 |
URI: |
https://boris.unibe.ch/id/eprint/103 (FactScience: 195884) |
Actions (login required)
 |
Edit item |