Lineage-specific transcription factor aberrations in AML

Mueller, Beatrice U; Pabst, Thomas (2010). Lineage-specific transcription factor aberrations in AML. Cancer treatment and research, 145, pp. 109-125. New York, N.Y.: Springer Science+Business Media

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Transcription factors play a key role in the commitment of hematopoietic stem cells to differentiate into specific lineages [78]. This is particularly important in that a block in terminal differentiation is the key contributing factor in acute leukemias. This general theme of the role of transcription factors in differentiation may also extend to other tissues, both in terms of normal development and cancer. Consistent with the role of transcription factors in hematopoietic lineage commitment is the frequent finding of aberrations in transcription factors in AML patients. Here, we intend to review recent findings on aberrations in lineage-restricted transcription factors as observed in patients with acute myeloid leukemia (AML).

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine > Centre of Competence for General Internal Medicine
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology

UniBE Contributor:

Müller, Beatrice Ursula and Pabst, Thomas

ISSN:

0927-3042

Publisher:

Springer Science+Business Media

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:07

Last Modified:

08 Jun 2016 10:19

PubMed ID:

20306248

URI:

https://boris.unibe.ch/id/eprint/103 (FactScience: 195884)

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