Quantum dot cytotoxicity in vitro: An investigation into the cytotoxic effects of a series of different surface chemistries and their core/shell materials

Clift, Martin J D; Varet, Julia; Hankin, Steven M; Brownlee, Bill; Davidson, Alan M; Brandenberger, Christina; Rothen-Rutishauser, Barbara; Brown, David M; Stone, Vicki (2010). Quantum dot cytotoxicity in vitro: An investigation into the cytotoxic effects of a series of different surface chemistries and their core/shell materials. Nanotoxicology, 5(4), pp. 664-674. London: Informa Healthcare 10.3109/17435390.2010.534196

Full text not available from this repository. (Request a copy)

Abstract The aim of this study was to assess the effects of a series of different surface coated quantum dots (QDs) (organic, carboxylated [COOH] and amino [NH(2)] polytethylene glycol [PEG]) on J774.A1 macrophage cell viability and to further determine which part of the QDs cause such toxicity. Cytotoxic examination (MTT assay and LDH release) showed organic QDs to induce significant cytotoxicity up to 48 h, even at a low particle concentration (20 nM), whilst both COOH and NH(2) (PEG) QDs caused reduced cell viability and cell membrane permeability after 24 and 48 h exposure at 80 nM. Subsequent analysis of the elements that constitute the QD core, core/shell and (organic QD) surface coating showed that the surface coating drives QD toxicity. Elemental analysis (ICP-AES) after 48 h, however, also observed a release of Cd from organic QDs. In conclusion, both the specific surface coating and core material can have a significant impact on QD toxicity.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy > Topographical and Clinical Anatomy

UniBE Contributor:

Clift, Martin

ISSN:

1743-5390

Publisher:

Informa Healthcare

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:09

Last Modified:

08 Jun 2016 10:20

Publisher DOI:

10.3109/17435390.2010.534196

PubMed ID:

21105833

Web of Science ID:

000296633100017

URI:

https://boris.unibe.ch/id/eprint/1038 (FactScience: 201734)

Actions (login required)

Edit item Edit item
Provide Feedback