Self-assembled α-Tocopherol Transfer Protein Nanoparticles Promote Vitamin E Delivery Across an Endothelial Barrier

Aeschimann, Walter; Staats, Stefanie; Kammer, Stephan Martin; Olieric, Natacha; Jeckelmann, Jean-Marc; Fotiadis, Dimitrios José; Netscher, Thomas; Rimbach, Gerald; Cascella, Michele; Stocker, Achim (2017). Self-assembled α-Tocopherol Transfer Protein Nanoparticles Promote Vitamin E Delivery Across an Endothelial Barrier (Unpublished). In: 52nd Bürgenstock Conference. Brunnen, Switzerland. 30th of April to 4th of May.

Vitamin E also known as α-tocopherol (α-Tol) is a natural antioxidant protecting unsaturated fatty acids in eukaryotic cell membranes from lipid peroxidation. The hepatic α-tocopherol transfer protein (α-TTP) exclusively sequesters α-Tol out of the eight naturally occurring vitamin E isomers. The supply mechanism of vitamin E through the cardiovascular system to peripheral tissues is yet not fully understood, but it is believed to occur through lipoproteins (VLDL). However, the central nervous system (CNS) is shielded from the blood stream by an endothelial cell layer called “blood brain barrier” (BBB) and forced to maintain its own set of lipoproteins. Failure of vitamin E homeostasis in the CNS cause a neurodegenerative disease called Ataxia with vitamin E deficiency (AVED). Usually, AVED is caused by inherited defects in the α-TTP gene. In this work we investigated by which means vitamin E is transported to the CNS.

Item Type:

Conference or Workshop Item (Poster)

Division/Institute:

08 Faculty of Science > Departement of Chemistry and Biochemistry

UniBE Contributor:

Aeschimann, Walter; Kammer, Stephan Martin; Jeckelmann, Jean-Marc; Fotiadis, Dimitrios José; Cascella, Michele and Stocker, Achim

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 540 Chemistry
600 Technology > 610 Medicine & health

Funders:

[42] Schweizerischer Nationalfonds
[UNSPECIFIED] CTCC Norway

Language:

English

Submitter:

Achim Stocker

Date Deposited:

16 Oct 2017 08:45

Last Modified:

16 Oct 2017 08:45

Additional Information:

Poster 25

URI:

https://boris.unibe.ch/id/eprint/104904

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