The clinical and prognostic value of motor abnormalities in psychosis, and the importance of instrumental assessment.

van Harten, Peter N; Walther, Sebastian; Kent, Jerillyn S; Sponheim, Scott R; Mittal, Vijay A (2017). The clinical and prognostic value of motor abnormalities in psychosis, and the importance of instrumental assessment. Neuroscience and biobehavioral reviews, 80, pp. 476-487. Elsevier 10.1016/j.neubiorev.2017.06.007

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Motor abnormalities comprise several clinical signs intrinsic to psychosis. Critically, these features are of prognostic value in individuals at-risk for psychosis, and for those in early stages of psychotic disorders. Motor abnormalities such as tremor, rigidity, and neurological soft signs often go unrecognized. Currently, advances in this area are limited by a paucity of theoretical conceptions categorizing or linking these behaviours to underlying neurobiology affected in psychosis. However, emerging technological advances have significantly improved the ability to detect and assess motor abnormalities with objective instruments in a timely and reliable manner. Further, converging evidence has laid the groundwork for theoretically and empirically derived categorization and conceptualization. This review summarizes these advances, stressing the importance of motor abnormalities for understanding vulnerability across different stages of psychosis and introducing these innovative instrumental approaches. Patients, researchers and clinicians will benefit from these new developments, as better assessment aids the development of targeted interventions to ultimately improve the care for individuals experiencing psychosis.

Item Type:

Journal Article (Review Article)


04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center

UniBE Contributor:

Walther, Sebastian


600 Technology > 610 Medicine & health








Sebastian Walther

Date Deposited:

19 Sep 2017 09:33

Last Modified:

19 Sep 2017 18:45

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Epidemiology Instrumental assessment Motor abnormalities Movement disorders Prognosis Psychosis Ultra high risk for psychosis




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