Beyond quality control: The role of nonsense-mediated mRNA decay (NMD) in regulating gene expression

Nasif, Sofia; Contu, Lara; Mühlemann, Oliver (2018). Beyond quality control: The role of nonsense-mediated mRNA decay (NMD) in regulating gene expression. Seminars in cell & developmental biology, 75, pp. 78-87. Elsevier 10.1016/j.semcdb.2017.08.053

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Nonsense-mediated mRNA decay (NMD) has traditionally been described as a quality control system that rids cells of aberrant mRNAs with crippled protein coding potential. However, transcriptome-wide profiling of NMD deficient cells identified a plethora of seemingly intact mRNAs coding for functional proteins as NMD targets. This led to the view that NMD constitutes an additional post-transcriptional layer of gene expression control involved in the regulation of many different biological pathways. Here, we review our current knowledge about the role of NMD in embryonic development and tissue-specific cell differentiation. We further summarize how NMD contributes to balancing of the integrated stress response and to cellular homeostasis of splicing regulators and NMD factors through auto-regulatory feedback loops. In addition, we discuss recent evidence that suggests a role for NMD as an innate immune response against several viruses. Altogether, NMD appears to play an important role in a broad spectrum of biological pathways, many of which still remain to be discovered.

Item Type:

Journal Article (Review Article)

Division/Institute:

08 Faculty of Science > Departement of Chemistry and Biochemistry

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Nasif, Sofia; Contu, Lara and Mühlemann, Oliver

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 540 Chemistry

ISSN:

1096-3634

Publisher:

Elsevier

Language:

English

Submitter:

Christina Schüpbach

Date Deposited:

16 Oct 2017 08:16

Last Modified:

26 Sep 2019 15:17

Publisher DOI:

10.1016/j.semcdb.2017.08.053

BORIS DOI:

10.7892/boris.105243

URI:

https://boris.unibe.ch/id/eprint/105243

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