Beyond quality control: The role of nonsense-mediated mRNA decay (NMD) in regulating gene expression

Nasif, Sofia; Contu, Lara; Mühlemann, Oliver (2018). Beyond quality control: The role of nonsense-mediated mRNA decay (NMD) in regulating gene expression. Seminars in cell & developmental biology, 75, pp. 78-87. Elsevier 10.1016/j.semcdb.2017.08.053

Nasif_SemCellDevBiol2017_Beyond quality control.pdf - Accepted Version
Available under License Creative Commons: Attribution-Noncommercial-No Derivative Works (CC-BY-NC-ND).

Download (682kB) | Preview
[img] Text
Nasif et al. SemCell Dev Biol 2018.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (2MB) | Request a copy

Nonsense-mediated mRNA decay (NMD) has traditionally been described as a quality control system that rids cells of aberrant mRNAs with crippled protein coding potential. However, transcriptome-wide profiling of NMD deficient cells identified a plethora of seemingly intact mRNAs coding for functional proteins as NMD targets. This led to the view that NMD constitutes an additional post-transcriptional layer of gene expression control involved in the regulation of many different biological pathways. Here, we review our current knowledge about the role of NMD in embryonic development and tissue-specific cell differentiation. We further summarize how NMD contributes to balancing of the integrated stress response and to cellular homeostasis of splicing regulators and NMD factors through auto-regulatory feedback loops. In addition, we discuss recent evidence that suggests a role for NMD as an innate immune response against several viruses. Altogether, NMD appears to play an important role in a broad spectrum of biological pathways, many of which still remain to be discovered.

Item Type:

Journal Article (Review Article)


08 Faculty of Science > Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP)

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Nasif, Sofia, Contu, Lara, Mühlemann, Oliver


500 Science > 570 Life sciences; biology
500 Science > 540 Chemistry








Christina Schüpbach

Date Deposited:

16 Oct 2017 08:16

Last Modified:

05 Dec 2022 15:07

Publisher DOI:





Actions (login required)

Edit item Edit item
Provide Feedback