Nasif, Sofia; Contu, Lara; Mühlemann, Oliver (2018). Beyond quality control: The role of nonsense-mediated mRNA decay (NMD) in regulating gene expression. Seminars in cell & developmental biology, 75, pp. 78-87. Elsevier 10.1016/j.semcdb.2017.08.053
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Nasif et al. SemCell Dev Biol 2018.pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Download (2MB) | Request a copy |
Nonsense-mediated mRNA decay (NMD) has traditionally been described as a quality control system that rids cells of aberrant mRNAs with crippled protein coding potential. However, transcriptome-wide profiling of NMD deficient cells identified a plethora of seemingly intact mRNAs coding for functional proteins as NMD targets. This led to the view that NMD constitutes an additional post-transcriptional layer of gene expression control involved in the regulation of many different biological pathways. Here, we review our current knowledge about the role of NMD in embryonic development and tissue-specific cell differentiation. We further summarize how NMD contributes to balancing of the integrated stress response and to cellular homeostasis of splicing regulators and NMD factors through auto-regulatory feedback loops. In addition, we discuss recent evidence that suggests a role for NMD as an innate immune response against several viruses. Altogether, NMD appears to play an important role in a broad spectrum of biological pathways, many of which still remain to be discovered.
Item Type: |
Journal Article (Review Article) |
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Division/Institute: |
08 Faculty of Science > Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP) |
Graduate School: |
Graduate School for Cellular and Biomedical Sciences (GCB) |
UniBE Contributor: |
Nasif, Sofia, Contu, Lara, Mühlemann, Oliver |
Subjects: |
500 Science > 570 Life sciences; biology 500 Science > 540 Chemistry |
ISSN: |
1096-3634 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Christina Schüpbach |
Date Deposited: |
16 Oct 2017 08:16 |
Last Modified: |
05 Dec 2022 15:07 |
Publisher DOI: |
10.1016/j.semcdb.2017.08.053 |
BORIS DOI: |
10.7892/boris.105243 |
URI: |
https://boris.unibe.ch/id/eprint/105243 |
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