Vitamin D supplementation differentially affects seasonal multiple sclerosis disease activity.

Miclea, Andrei; Miclea, Marius; Pistor, Maximilian; Hoepner, Andreas; Chan, Andrew; Hoepner, Robert (2017). Vitamin D supplementation differentially affects seasonal multiple sclerosis disease activity. Brain and Behavior, 7(8), e00761. Wiley 10.1002/brb3.761

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OBJECTIVES Low ultraviolet-B (UVB) radiation causes hypovitaminosis D, which is a known risk factor for multiple sclerosis (MS) and associated with MS disease activity. Our objective is to test whether vitamin D supplementation is most effective in lowering disease activity during the period of the year with low UVB radiation and consequently low serum 25-hydroxyvitamin D3 (25(OH)D3) concentration. METHODS Retrospective analysis of medical records from our outpatient department identified 40 MS patients with available data of at least 6 months before and during oral vitamin D supplementation. Serum 25(OH)D3 concentration was analyzed using immunoassay. UVB radiation data were provided by the local government. Annualized and quarterly relapse rates before and during vitamin D supplementation served as outcome parameters. RESULTS During vitamin D supplementation (18,950 international units/week (mean, SD 3,397)), serum 25(OH)D3 concentration increased by 51 nmol/L and the UVB-related seasonal variability in 25(OH)D3 levels ceased (rho = -0.13, p > .05). Furthermore, the annualized relapse rate decreased by approximately 50%. This was almost solely driven by the prominent reduction in the quarterly relapse rate in late winter/early spring, when 25(OH)D3 levels of nonsupplemented patients were the lowest. CONCLUSIONS Our study demonstrated the modulation of seasonal MS disease activity through vitamin D supplementation. Given the prominent reduction in the quarterly relapse rate in late winter/early spring, our data indicate a beneficial effect of supplementing MS patients with vitamin D, especially during this period of the year.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Chan, Andrew and Hoepner, Robert

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2162-3279

Publisher:

Wiley

Language:

English

Submitter:

Stefanie Hetzenecker

Date Deposited:

07 Nov 2017 16:10

Last Modified:

21 Aug 2018 16:05

Publisher DOI:

10.1002/brb3.761

PubMed ID:

28828221

Uncontrolled Keywords:

25(OH)D3 Calcitriol relapse seasonality ultraviolet‐B winter

BORIS DOI:

10.7892/boris.105262

URI:

https://boris.unibe.ch/id/eprint/105262

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