Performance evaluation of a collapsed cone dose calculation algorithm for HDR Ir-192 of APBI treatments.

Terribilini, Dario; Vitzthum, Veronika; Volken, Werner; Frei, Daniel; Lössl, Kristina; van Veelen, Bob; Manser, Peter; Fix, Michael (2017). Performance evaluation of a collapsed cone dose calculation algorithm for HDR Ir-192 of APBI treatments. Medical physics, 44(10), pp. 5475-5485. American Association of Physicists in Medicine AAPM 10.1002/mp.12490

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PURPOSE Most dose calculations for HDR brachytherapy treatments are based on the AAPM-TG43 formalism. Because patient's anatomy, heterogeneities, and applicator shielding are not considered, the dose calculation based on this formalism is inaccurate in some cases. Alternatively, collapsed cone (CC) methods as well as Monte Carlo (MC) algorithms belong to the model-based dose calculation algorithms, which are expected to improve the accuracy of calculated dose distributions. In this work, the performance of a CC algorithm, ACE in Oncentra Brachy 4.5 (ACE 4.5), has been investigated by comparing the calculated dose distributions to the AAPM-TG43 and MC calculations for 10 HDR brachytherapy accelerated partial breast irradiation treatments (APBI). Comparisons were also performed with a corrected version of ACE 4.5 (ACE 4.5/corr). METHODS The brachytherapy source microSelectron mHDR-v2 (Elekta Brachytherapy) has been implemented in a MC environment and validated by comparing MC dose distributions simulated in a water phantom of 80 cm in diameter with dose distributions calculated with the AAPM-TG43 algorithm. Dose distributions calculated with ACE 4.5, ACE 4.5/corr, AAPM-TG43 formalism, and MC for 10 APBI patients plans have then been computed and compared using HU scaled densities. In addition, individual dose components have been computed using ACE 4.5, ACE 4.5/corr, and MC, and compared individually. RESULTS Local differences between MC and AAPM-TG43 calculated dose distributions in a large water phantom are < 1%. When using HUs scaled densities for the breast cancer patients, both accuracy levels of ACE 4.5 overestimate the MC calculated dose distributions for all analyzed dosimetric parameters. In the planning target volume (PTV), ACE 4.5 (ACE 4.5/corr) overestimates on average V100%,PTV by 3% ± 1% (1% ± 1%) and D50,PTV by 3% ± 1% (1% ± 1%) and in the organs at risk D1cc, skin by 4% ± 2% (1% ± 1%), D0.5cc, ribs by 4% ± 2% (0% ± 1%), and D1cc, heart by 8% ± 2% (3% ± 1%) compared to MC. Comparisons of the individual dose components reveals an agreement for the primary component of < 2% local differences for both ACE 4.5 and ACE 4.5/corr. Local differences of about 40% (20%) for the first and residual scatter components where observed when using ACE 4.5 (ACE 4.5/corr). Using uniform densities for one case shows a better agreement between ACE 4.5 and MC for all dosimetric parameters considered in this work. CONCLUSIONS In general, on the 10 APBI patients the ACE 4.5/corr algorithm results in similar dose distributions as the commonly used AAPM-TG43 within the PTV. However, the accuracy of the ACE 4.5/corr calculated dose distribution is closer to MC than to AAPM-TG43. The differences between commercial version ACE 4.5 and MC dose distributions are mainly located in the first and residual scatter components. In ACE 4.5/corr, the changes done in the algorithm for the scatter components substantially reduce these differences.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology > Medical Radiation Physics
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology

UniBE Contributor:

Terribilini, Dario; Vitzthum, Veronika; Volken, Werner; Frei, Daniel; Lössl, Kristina; Manser, Peter and Fix, Michael

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0094-2405

Publisher:

American Association of Physicists in Medicine AAPM

Language:

English

Submitter:

Beatrice Scheidegger

Date Deposited:

06 Mar 2018 13:29

Last Modified:

06 Mar 2018 13:37

Publisher DOI:

10.1002/mp.12490

PubMed ID:

28750134

Uncontrolled Keywords:

APBI Monte Carlo brachytherapy collapsed cone dose calculation algorithm

BORIS DOI:

10.7892/boris.105273

URI:

https://boris.unibe.ch/id/eprint/105273

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