REM Sleep EEG Instability in REM Sleep Behavior Disorder and Clonazepam Effects.

Ferri, Raffaele; Rundo, Francesco; Silvani, Alessandro; Zucconi, Marco; Bruni, Oliviero; Ferini-Strambi, Luigi; Plazzi, Giuseppe; Manconi, Mauro (2017). REM Sleep EEG Instability in REM Sleep Behavior Disorder and Clonazepam Effects. Sleep, 40(8) Oxford University Press 10.1093/sleep/zsx080

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Study Objectives

We aimed to analyze quantitatively rapid eye movement (REM) sleep electroencephalogram (EEG) in controls, drug-naïve idiopathic REM sleep behavior disorder patients (iRBD), and iRBD patients treated with clonazepam.

Methods

Twenty-nine drug-naïve iRBD patients (mean age 68.2 years), 14 iRBD patients under chronic clonazepam therapy (mean age 66.3 years), and 21 controls (mean age 66.8 years) were recruited. Power spectra were obtained from sleep EEG (central derivation), using a 2-second sliding window, with 1-second steps. The power values of each REM sleep EEG spectral band (one every second) were normalized with respect to the average power value obtained during sleep stage 2 in the same individual.

Results

In drug-naïve patients, the normalized power values showed a less pronounced REM-related decrease of power in all bands with frequency <15 Hz than controls and an increase in the beta band, negatively correlated with muscle atonia; in patients treated with clonazepam there was a partial return of all bands <15 Hz toward the control values. The standard deviation values of the normalized power were higher for untreated patients in all EEG bands and were almost completely normalized in patients treated with clonazepam.

Conclusions

The REM sleep EEG structure changes found in this study disclose subtle but significant alterations in the cortical electrophysiology of RBD that might represent the early expression of the supposed neurodegenerative processes already taking place at this stage of the disease and might be the target of better and effective future therapeutic strategies for this condition.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology
UniBE Contributor:	Manconi, Mauro
Subjects:	600 Technology > 610 Medicine & health
ISSN:	1550-9109
Publisher:	Oxford University Press
Language:	English
Submitter:	Stefanie Hetzenecker
Date Deposited:	07 Nov 2017 15:08
Last Modified:	05 Dec 2022 15:07
Publisher DOI:	10.1093/sleep/zsx080
PubMed ID:	28482056
Uncontrolled Keywords:	Electroencephalography Neurodegeneration REM Sleep REM Sleep Behavior Disorder REM sleep without atonia Synucleinopathy
URI:	https://boris.unibe.ch/id/eprint/105281