T1-2 glottic cancer treated with radiotherapy and/or surgery.

Shelan, Mohamed; Anschuetz, Lukas; Schubert, Adrian D; Bojaxhiu, Beat; Dal Pra, Alan; Behrensmeier, Frank; Aebersold, Daniel; Giger, Roland; Eliçin, Olgun (2017). T1-2 glottic cancer treated with radiotherapy and/or surgery. Strahlentherapie und Onkologie, 193(12), pp. 995-1004. Springer-Medizin-Verlag 10.1007/s00066-017-1139-4

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BACKGROUND The optimal treatment strategy for stage I-II glottic squamous cell carcinoma (SCC) is not well-defined. This study analyzed treatment results and prognostic factors. PATIENTS AND METHODS This is a single-institution retrospective analysis of 244 patients with T1-2 glottic SCC who underwent normofractionated radiotherapy (RT) and/or surgery between 1990 and 2013. The primary endpoint was relapse-free survival (RFS). RESULTS Median age was 65 years (range: 36-92 years), the majority (82%) having stage I disease. Definitive RT was used in 82% (median dose: 68 Gy, 2 Gy per fraction). Median follow-up was 59 months. The 5‑year RFS rates were 83 and 75% (p = 0.05) for stage I and 62 and 50% (p = 0.47) for stage II in the RT and surgery groups, respectively. Multivariate analyses indicate T1 vs. T2 and RT vs. surgery as independent prognostic factors for RFS, with hazard ratios of 0.38 (95% confidence interval, CI: 0.21-0.72) and 0.53 (95% CI: 0.30-0.99), respectively (p < 0.05). The 5‑year overall and cause-specific survival rates in the whole cohort were 92 and 96%, respectively, with no significant differences between treatment groups. Anterior commissure involvement was neither a prognostic nor a predictive factor. The incidence of secondary malignancies was not significantly different between patients treated with and without RT (22 vs. 9% at 10 years, respectively, p = 0.18). CONCLUSION Despite a possible selection bias, our series demonstrates improved RFS with RT over surgery in stage I glottic SCC.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ear, Nose and Throat Disorders (ENT)

UniBE Contributor:

Shelan, Mohamed; Bojaxhiu, Beat; Dal Pra, Alan; Behrensmeier, Frank; Aebersold, Daniel; Giger, Roland and Eliçin, Olgun

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0179-7158

Publisher:

Springer-Medizin-Verlag

Language:

English

Submitter:

Beatrice Scheidegger

Date Deposited:

23 Feb 2018 15:12

Last Modified:

01 Jan 2019 02:30

Publisher DOI:

10.1007/s00066-017-1139-4

PubMed ID:

28474090

Uncontrolled Keywords:

Carcinoma, squamous cell Laryngeal neoplasms Laryngectomy Microsurgery Survival

BORIS DOI:

10.7892/boris.105286

URI:

https://boris.unibe.ch/id/eprint/105286

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