Eosinophils as putative therapeutic targets in bullous pemphigoid.

Simon, Dagmar; Borradori, Luca; Simon, Hans-Uwe (2017). Eosinophils as putative therapeutic targets in bullous pemphigoid. Experimental dermatology, 26(12), pp. 1187-1192. Blackwell 10.1111/exd.13416

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Bullous pemphigoid (BP) is the most common autoimmune subepidermal blistering skin disease and is characterized by the presence of autoantibodies directed against the hemidesmosomal proteins BP180 and BP230 that can be detected in the skin and serum of BP patients. Histologically, the dermal infiltration of eosinophils is obvious. The objective of this review is to present evidence that eosinophils play a key role in the pathogenesis of BP. Eosinophils, together with cytokines and chemokines regulating their production, recruitment and activation, are abundantly present in lesional skin, in blisters and in peripheral blood of patients with BP. Recently, using a cryosection model, eosinophils were demonstrated to induce dermal-epidermal separation in the presence of BP antibodies. Thus, eosinophils and their products, as well as mediators regulating their function, present promising targets for the treatment of BP. This article is protected by copyright. All rights reserved.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology

UniBE Contributor:

Simon, Dagmar; Borradori, Luca and Simon, Hans-Uwe

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0906-6705

Publisher:

Blackwell

Language:

English

Submitter:

Jana Berger

Date Deposited:

19 Oct 2017 16:09

Last Modified:

21 Aug 2018 02:30

Publisher DOI:

10.1111/exd.13416

PubMed ID:

28833620

Uncontrolled Keywords:

BP auto-antibodies Bullous pemphigoid Eosinophils dermal-epidermal separation

BORIS DOI:

10.7892/boris.105411

URI:

https://boris.unibe.ch/id/eprint/105411

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