Behavioral Changes in Patients with Multiple Sclerosis.

Heldner, Mirjam Rachel; Kaufmann-Ezra, Sigal; Gutbrod, Klemens; Bernasconi, Corrado Angelo; Bigi, Sandra; Blatter Arifi, Verena; Mattle, Heinrich; Müri, René Martin; Verma, Rajeev Kumar; Kamm, Christian Philipp (2017). Behavioral Changes in Patients with Multiple Sclerosis. Frontiers in neurology, 8(437), p. 437. Frontiers Media S.A. 10.3389/fneur.2017.00437

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Behavioral changes are common in patients with multiple sclerosis (MS), however not as readily recognized as cognitive impairments.


The aim of this study was to analyze behavioral changes and its relation to disease characteristics, disability, and cognitive impairments in patients with MS.


This is a single-center cross-sectional study. A detailed neuropsychological examination, including the Frontal Systems Behavior Scale (FrSBe), the Beck depression inventory (BDI), and the Wuerzburg Fatigue Inventory for Multiple Sclerosis (WEIMuS) test, was performed. FrSBe results were correlated with disease characteristics, disability, and cognitive assessments.


66 patients were enrolled (mean age: 43.4 years; disease duration: 9.3 years; Expanded Disability Status Scale: 3.0). Up to one third of patients showed behavioral changes in at least one domain or the total score of the FrSBe. Patients were mildly affected with regard to cognitive functioning. Consistent correlation was found between behavioral changes and fatigue (WEIMuS) and depressive symptoms (BDI), but not with disease characteristics, disability, or cognitive functions. There was an increase of behavioral changes on all FrSBe scales in the current status compared to the retrospectively rated status before disease onset. Self- and family ratings with regard to current behavioral changes were similar.


Behavioral changes are common in otherwise mildly affected MS patients with up to one third being affected. In this patient cohort, behavioral changes occur largely independent of disease characteristics, physical disability, and cognitive functioning but correlate with both fatigue and depressive symptoms. Therefore, they should be tested specifically.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology

UniBE Contributor:

Heldner, Mirjam Rachel, Kaufmann-Ezra, Sigal, Gutbrod, Klemens, Bernasconi, Corrado Angelo, Bigi, Sandra, Blatter Arifi, Verena, Mattle, Heinrich, Müri, René Martin, Verma, Rajeev Kumar, Kamm, Christian Philipp


600 Technology > 610 Medicine & health




Frontiers Media S.A.




Anette van Dorland

Date Deposited:

23 Oct 2017 07:39

Last Modified:

05 Dec 2022 15:07

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Frontal Systems Behavior Scale behavioral changes cognition disability evaluation multiple sclerosis




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