Gray matter asymmetries in aging and neurodegeneration: A review and meta-analysis.

Minkova, Lora; Habich, Annegret; Peter, Jessica; Kaller, Christoph P; Eickhoff, Simon B; Klöppel, Stefan (2017). Gray matter asymmetries in aging and neurodegeneration: A review and meta-analysis. Human brain mapping, 38(12), pp. 5890-5904. Wiley-Blackwell 10.1002/hbm.23772

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Inter-hemispheric asymmetries are a common phenomenon of the human brain. Some evidence suggests that neurodegeneration related to aging and disease may preferentially affect the left-usually language- and motor-dominant-hemisphere. Here, we used activation likelihood estimation meta-analysis to assess gray matter (GM) loss and its lateralization in healthy aging and in neurodegeneration, namely, mild cognitive impairment (MCI), Alzheimer's dementia (AD), Parkinson's disease (PD), and Huntington's disease (HD). This meta-analysis, comprising 159 voxel-based morphometry publications (enrolling 4,469 patients and 4,307 controls), revealed that GM decline appeared to be asymmetric at trend levels but provided no evidence for increased left-hemisphere vulnerability. Regions with asymmetric GM decline were located in areas primarily affected by neurodegeneration. In HD, the left putamen showed converging evidence for more pronounced atrophy, while no consistent pattern was found in PD. In MCI, the right hippocampus was more atrophic than its left counterpart, a pattern that reversed in AD. The stability of these findings was confirmed using permutation tests. However, due to the lenient threshold used in the asymmetry analysis, further work is needed to confirm our results and to provide a better understanding of the functional role of GM asymmetries, for instance in the context of cognitive reserve and compensation. Hum Brain Mapp, 2017. © 2017 Wiley Periodicals, Inc.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Geriatric Psychiatry and Psychotherapy
10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research

UniBE Contributor:

Habich, Annegret; Peter, Jessica and Klöppel, Stefan

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

1065-9471

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Katharina Klink

Date Deposited:

21 Sep 2017 15:19

Last Modified:

10 Nov 2017 01:31

Publisher DOI:

10.1002/hbm.23772

PubMed ID:

28856766

Uncontrolled Keywords:

ALE Huntington's disease Parkinson's disease VBM aging dementia

BORIS DOI:

10.7892/boris.105488

URI:

https://boris.unibe.ch/id/eprint/105488

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