OCT-angiography: A qualitative and quantitative comparison of 4 OCT-A devices.

Munk, Marion R; Zimmermann, Helena; Berger, Lieselotte Erika; Huf, Wolfgang; Ebneter, Andreas; Wolf, Sebastian; Zinkernagel, Martin (2017). OCT-angiography: A qualitative and quantitative comparison of 4 OCT-A devices. PLoS ONE, 12(5), e0177059. Public Library of Science 10.1371/journal.pone.0177059

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PURPOSE To compare the quality of four OCT-angiography(OCT-A) modules. METHOD The retina of nineteen healthy volunteers were scanned with four OCT-devices (Topcon DRI-OCT Triton Swept-source OCT, Optovue RTVue-XR, a prototype Spectralis OCT2, Heidelberg-Engineering and Zeiss Cirrus 5000-HD-OCT). The device-software generated en-face OCT-A images of the superficial (SCP) and deep capillary plexuses (DCP) were evaluated and scored by 3 independent retinal imaging experts. The SCP vessel density was assessed using Angiotool-software. After the inter-grader reliability assessment, a consensus grading was performed and the modules were ranked based on their scoring. RESULTS There was no significant difference in the vessel density among the modules (Zeiss 48.7±4%, Optovue 47.9±3%, Topcon 48.3±2%, Heidelberg 46.5±4%, p = 0.2). The numbers of discernible vessel-bifurcations differed significantly on each module (Zeiss 2±0.9 bifurcations, Optovue 2.5±1.2, Topcon 1.3±0.7 and Heidelberg 0.5±0.6, p≤0.001). The ranking of each module differed depending on the evaluated parameter. In the overall ranking, the Zeiss module was superior and in 90% better than the median (Bonferroni corrected p-value = 0.04). Optovue was better than the median in 60%, Topcon in 40% and Heidelberg module in 10%, however these differences were not statistically significant. CONCLUSION Each of the four evaluated OCT-A modules had particular strengths, which differentiated it from their competitors.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology

UniBE Contributor:

Zimmermann, Helena; Berger, Lieselotte Erika; Ebneter, Andreas; Wolf, Sebastian and Zinkernagel, Martin

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1932-6203

Publisher:

Public Library of Science

Language:

English

Submitter:

Sebastian Wolf

Date Deposited:

09 Nov 2017 13:41

Last Modified:

09 Nov 2017 13:48

Publisher DOI:

10.1371/journal.pone.0177059

PubMed ID:

28489918

BORIS DOI:

10.7892/boris.105554

URI:

https://boris.unibe.ch/id/eprint/105554

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