Angiotensinergic neurotransmission in the peripheral autonomic nervous system.

Bohlender, Jürgen; Imboden, Hans (2012). Angiotensinergic neurotransmission in the peripheral autonomic nervous system. Frontiers in bioscience - Landmark edition, 17(7), pp. 2419-2432. Frontiers in Bioscience 10.2741/4062

[img] Text
getfile.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (820kB) | Request a copy

Angiotensin (Ang) II has for long been identified as a neuropeptide located within neurons and pathways of the central nervous system involved in the control of thirst and cardio-vascular homeostasis. The presence of Ang II in ganglionic neurons of celiac, dorsal root, and trigeminal ganglia has only recently been described in humans and rats. Ang II-containing fibers were also found in the mesenteric artery and the heart, together with intrinsic Ang II-containing cardiac neurons. Ganglionic neurons express angiotensinogen and co-localize it with Ang II. Its intraneuronal production as a neuropeptide appears to involve angiotensinogen processing enzymes other than renin. Immunocytochemical and gene expression data suggest that neuronal Ang II acts as a neuromodulatory peptide and co-transmitter in the peripheral autonomic, and also sensory nervous system. Neuronal Ang II probably competes with humoral Ang II for effector cell activation. Its functional role, however, still remains to be determined. Angiotensinergic neurotransmission in the autonomic nervous system is a potential new target for therapeutic interventions in many common diseases such as essential hypertension, heart failure, and cardiac arrhythmia.

Item Type:

Journal Article (Review Article)


08 Faculty of Science > Department of Biology > Institute of Cell Biology

UniBE Contributor:

Bohlender, Jürgen


500 Science > 570 Life sciences; biology




Frontiers in Bioscience




Jürgen Bohlender

Date Deposited:

20 Jun 2018 14:19

Last Modified:

22 Oct 2019 18:35

Publisher DOI:


PubMed ID:





Actions (login required)

Edit item Edit item
Provide Feedback