3D-constructive interference into steady state (3D-CISS) labyrinth signal alteration in patients with vestibular schwannoma.

Wagner, Franca; Herrmann, Evelyn; Wiest, Roland; Raabe, Andreas; Bernasconi, Corrado Angelo; Caversaccio, Marco; Vibert-Mennet, Dominique (2018). 3D-constructive interference into steady state (3D-CISS) labyrinth signal alteration in patients with vestibular schwannoma. Auris, nasus, larynx, 45(4), pp. 702-710. Elsevier 10.1016/j.anl.2017.09.011

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OBJECTIVE To evaluate signal intensity of the inner ear using 3D-CISS imaging and correlated signal characteristics in patients with vestibular schwannoma to neuro-otological symptoms. METHODS Sixty patients with unilateral vestibular schwannoma were retrospectively reviewed. All patients had had initial and follow-up magnetic resonance imaging (MRI). Individual treatment strategies consisted of "wait-and-watch", surgical tumour resection, stereotactic radiosurgery or both surgery and stereotactic radiosurgery. For all patients a complete baseline and treatment course neuro-otological examination was re-studied. RESULTS On initial MRI, 3D-CISS sequence signal loss of the membranous labyrinth was present in 20 patients (33.3%); signal loss of cochlea in 20 (33.3%) and coincident signal loss of sacculus/utriculus in 17 (85%) of them. Sequential analysis of follow-up MRI series demonstrated slightly increased labyrinthine signal degradation, independently of the chosen therapy. Correlation of initial MRI results with initial neuro-otological symptoms showed significance only for cochlear obstruction versus vertigo (p=0.0397) and sacculus/utriculus obstruction versus vertigo (p=0.0336). No other statistically significant relationships were noted. CONCLUSION 3D-constructive interference into steady state (3D-CISS) is appropriate for observing inner ear signal loss in patients with vestibular schwannoma. However, except for vertigo, no significant correlation was noted between initial neuro-otological symptomatology and signal loss of the inner ear.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ear, Nose and Throat Disorders (ENT)
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurosurgery
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology

UniBE Contributor:

Wagner, Franca; Herrmann, Evelyn; Wiest, Roland; Raabe, Andreas; Bernasconi, Corrado Angelo; Caversaccio, Marco and Vibert-Mennet, Dominique

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1879-1476

Publisher:

Elsevier

Language:

English

Submitter:

Martin Zbinden

Date Deposited:

14 Nov 2017 15:52

Last Modified:

20 May 2018 01:30

Publisher DOI:

10.1016/j.anl.2017.09.011

PubMed ID:

28947096

Uncontrolled Keywords:

3D-CISS Labyrinth signal loss MRI Treatment Vertigo Vestibular schwannoma

BORIS DOI:

10.7892/boris.105917

URI:

https://boris.unibe.ch/id/eprint/105917

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