Microvesicles in vascular homeostasis and diseases. Position Paper of the European Society of Cardiology (ESC) Working Group on Atherosclerosis and Vascular Biology.

Ridger, Victoria C; Boulanger, Chantal M; Angelillo, Anne; Badimon, Lina; Blanc-Brude, Olivier; Bochaton-Piallat, Marie-Luce; Boilard, Eric; Buzas, Edit I; Caporali, Andreas; Dignat-George, Françoise; Evans, Paul C; Lacroix, Romaric; Lutgens, Esther; Ketelhuth, Daniel F J; Nieuwland, Rienk; Toti, Florence; Tunon, Jose; Weber, Christian; Hoefer, Imo E (2017). Microvesicles in vascular homeostasis and diseases. Position Paper of the European Society of Cardiology (ESC) Working Group on Atherosclerosis and Vascular Biology. Thrombosis and haemostasis, 117(7), pp. 1296-1316. Schattauer 10.1160/TH16-12-0943

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Microvesicles are members of the family of extracellular vesicles shed from the plasma membrane of activated or apoptotic cells. Microvesicles were initially characterised by their pro-coagulant activity and described as "microparticles". There is mounting evidence revealing a role for microvesicles in intercellular communication, with particular relevance to hemostasis and vascular biology. Coupled with this, the potential of microvesicles as meaningful biomarkers is under intense investigation. This Position Paper will summarise the current knowledge on the mechanisms of formation and composition of microvesicles of endothelial, platelet, red blood cell and leukocyte origin. This paper will also review and discuss the different methods used for their analysis and quantification, will underline the potential biological roles of these vesicles with respect to vascular homeostasis and thrombosis and define important themes for future research.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Haematology and Central Haematological Laboratory
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Unit Childrens Hospital > Forschungsgruppe Hämatologie (Erwachsene)

UniBE Contributor:

Angelillo, Anne

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0340-6245

Publisher:

Schattauer

Language:

English

Submitter:

Katrin Kölliker-Schütz

Date Deposited:

11 Dec 2017 08:14

Last Modified:

03 Nov 2019 11:55

Publisher DOI:

10.1160/TH16-12-0943

PubMed ID:

28569921

Uncontrolled Keywords:

Atherothrombosis cell-cell interactions inflammatory mediators macrophage / Angelillo-Scherrer Anne

BORIS DOI:

10.7892/boris.106214

URI:

https://boris.unibe.ch/id/eprint/106214

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