Motor System Pathology in Psychosis.

Walther, Sebastian; Mittal, Vijay A (2017). Motor System Pathology in Psychosis. Current psychiatry reports, 19(12), p. 97. Springer 10.1007/s11920-017-0856-9

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PURPOSE OF REVIEW Motor abnormalities are an intrinsic feature of psychosis. Neurological soft signs, Parkinsonism, dyskinesia, and other motor phenomena are frequently observed in subjects at clinical or genetic risk for psychosis as well as first-episode patients, chronic patients. Here, we review the most recent literature on motor assessments and pathophysiology in psychosis. RECENT FINDINGS Instrumental measures of fine motor performance, balance, spontaneous motor activity, and gesture indicated motor abnormalities in subjects at risk and across stages of schizophrenia. Motor phenomena are associated with distinct symptom dimensions and may indicate poor outcomes. Neuroimaging studies demonstrated altered neural maturation within critical motor networks in subjects at risk. Furthermore, specific categories of motor dysfunction were associated with distinct structural and functional alterations in the motor system in schizophrenia. Motor abnormalities provide a unique window into the pathobiology of psychosis and have the potential to guide screening, staging, and outcome prediction.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center

UniBE Contributor:

Walther, Sebastian

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1535-1645

Publisher:

Springer

Language:

English

Submitter:

Sebastian Walther

Date Deposited:

11 Dec 2017 11:07

Last Modified:

09 Nov 2019 18:47

Publisher DOI:

10.1007/s11920-017-0856-9

PubMed ID:

29086118

Uncontrolled Keywords:

Motor Movement abnormality Psychosis Schizophrenia

BORIS DOI:

10.7892/boris.107094

URI:

https://boris.unibe.ch/id/eprint/107094

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