Ribi, Karin; Rondeau, Stéphanie; Hitz, Felicitas; Mey, Ulrich; Enoiu, Milica; Pabst, Thomas; Stathis, Anastasios; Fischer, Natalie; Clough-Gorr, Kerri M (2017). Cancer-specific geriatric assessment and quality of life: important factors in caring for older patients with aggressive B-cell lymphoma. Supportive care in cancer, 25(9), pp. 2833-2842. Springer 10.1007/s00520-017-3698-4
|
Text
Ribi SupportCareCancer 2017.pdf - Published Version Available under License Publisher holds Copyright. Download (422kB) | Preview |
|
|
Text
Ribi SupportCareCancer 2017_postprint.pdf - Accepted Version Available under License Publisher holds Copyright. Download (296kB) | Preview |
PURPOSE
To evaluate the efficacy and tolerability of chemotherapy, a geriatric assessment is recommended in elderly patients with cancer. We aimed to characterize and compare patients with aggressive lymphoma by objective response and survival status based on pre-treatment cancer-specific geriatric (C-SGA) and quality of life (QoL) assessments.
METHODS
Patients not eligible for anthracycline-based first-line therapy or intensive salvage regimens completed C-SGA and QoL assessment before and after a rituximab-bendamustine-lenalidomide (R-BL) treatment in a phase II clinical trial. Clinical outcomes were compared based on pre-treatment individual and summary C-SGA measures, their cutoff-based subcategories and QoL indicators, using Wilcoxon rank sum or chi-square tests.
RESULTS
A total of 57 patients (41 included in the clinical trial) completed a C-SGA. Participants with pre-treatment impaired functional status (Vulnerable Elders Survey-13 score ≥3) were more likely to experience worse outcomes: a higher proportion were non-responders, died before the median follow-up of 31.6 months (interquartile range (IQR) 27.9-37.9) or died during treatment. Non-responders were patients categorized as having possible depression (Geriatric Depression Scale-5 score ≥2) and with worse QoL scores for functional performance. Patients with worse C-SGA summary scores and with greater tiredness were more likely to die during treatment.
CONCLUSION
A pre-treatment impaired functional status is an important factor with respect to clinical outcomes in patients receiving an R-BL regimen. Individual geriatric and related QoL domains showed similar associations with clinical outcomes. Whether interventions targeting specific geriatric dimensions also translate in better symptom- or domain-specific QoL warrants further research.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology 04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM) |
UniBE Contributor: |
Pabst, Thomas Niklaus, Clough, Kerri |
Subjects: |
600 Technology > 610 Medicine & health 300 Social sciences, sociology & anthropology > 360 Social problems & social services |
ISSN: |
0941-4355 |
Publisher: |
Springer |
Language: |
English |
Submitter: |
Tanya Karrer |
Date Deposited: |
09 Jan 2018 11:53 |
Last Modified: |
02 Mar 2023 23:29 |
Publisher DOI: |
10.1007/s00520-017-3698-4 |
PubMed ID: |
28405846 |
Uncontrolled Keywords: |
Aggressive B-cell lymphoma Geriatric assessment Quality of life Rituximab-bendamustine-lenalidomide treatment |
BORIS DOI: |
10.7892/boris.107135 |
URI: |
https://boris.unibe.ch/id/eprint/107135 |
Actions (login required)
 |
Edit item |