Decreased oxygen saturation levels in neonates with transposition of great arteries: Impact on appearance of cerebral veins in susceptibility-weighted imaging.

Verma, Rajeev Kumar; Keller, Desislava; Grunt, Sebastian; Bigi, Sandra; Weisstanner, Christian; Wiest, Roland; Gralla, Jan; Hutter, Damian Marco; Wagner, Bendicht Peter (2017). Decreased oxygen saturation levels in neonates with transposition of great arteries: Impact on appearance of cerebral veins in susceptibility-weighted imaging. Scientific Reports, 7(1), p. 15471. Nature Publishing Group 10.1038/s41598-017-15591-3

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Purpose of this study was to investigate a potential correlation between the pattern of cerebral veins (CV) on susceptibility-weighted imaging (SWI) and blood oxygen saturation, as well as preoperative brain injury, in neonates with transposition of the great arteries (TGA). Eleven neonates with TGA underwent MRI preoperatively, including SWI, T1- and T2-weighted scans. Images were retrospectively evaluated and appearance of CV was graded from 0 (normal appearance) to 3 (severe prominent appearance). White matter injuries (WMI) and strokes were analysed. Results were correlated with preductal arterial oxygen saturation. As findings one subject showed a normal CV appearance (grade 0) whereas 10 showed pathological prominent CV (grades 1-3); median 2. Mean oxygen saturation ranged between 67.5% and 89.0% (median 81.0%). CV grade and mean oxygen saturation correlated significantly (p = 0.011). WMI were absent in 5 cases, mild in 4, and moderate in 2 cases. We conclude, that SWI has the potential to be used to estimate the current hypoxic burden on brain tissue in TGA newborns by assessing the prominence of the CV.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology

UniBE Contributor:

Verma, Rajeev Kumar; Keller, Desislava; Grunt, Sebastian; Bigi, Sandra; Weisstanner, Christian; Wiest, Roland; Gralla, Jan; Hutter, Damian Marco and Wagner, Bendicht Peter

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2045-2322

Publisher:

Nature Publishing Group

Language:

English

Submitter:

Stefanie Hetzenecker

Date Deposited:

04 Dec 2017 14:27

Last Modified:

10 Dec 2017 02:23

Publisher DOI:

10.1038/s41598-017-15591-3

PubMed ID:

29133891

BORIS DOI:

10.7892/boris.107253

URI:

https://boris.unibe.ch/id/eprint/107253

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