The Role of IL-33-Dependent Inflammation in the Tumor Microenvironment

Wasmer, Marie-Hélène; Krebs, Philippe (2017). The Role of IL-33-Dependent Inflammation in the Tumor Microenvironment. Frontiers in immunology, 7(682), p. 682. Frontiers Research Foundation 10.3389/fimmu.2016.00682

[img]
Preview
Text
fimmu-07-00682.pdf - Published Version
Available under License Creative Commons: Attribution (CC-BY).

Download (1MB) | Preview

There is compelling evidence that inflammation contributes to tumorigenesis. Inflammatory mediators within the tumor microenvironment can either promote an antitumor immune response or support tumor pathogenesis. Therefore, it is critical to determine the relative contribution of tumor-associated inflammatory pathways to cancer development. Interleukin-33 (IL-33) is a member of the IL-1 family of cytokines that is released upon tissue stress or damage to operate as an alarmin. IL-33 has been primarily implicated in the induction of type-2 immune responses. However, recent findings have shown a role of IL-33 in several cancers where it may exert multiple functions. In this review, we will present the current knowledge on the role of IL-33 in the microenvironment of different tumors. We will highlight which cells produce and which cells are activated by IL-33 in cancer. Furthermore, we will explain how IL-33 modulates the tumor-associated inflammatory microenvironment to restrain or promote tumorigenesis. Finally, we will discuss the issues to be addressed first before potentially targeting the IL-33 pathway for cancer therapy.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology > Immunopathology
04 Faculty of Medicine > Service Sector > Institute of Pathology

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Wasmer, Marie-Hélène and Krebs, Philippe

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

1664-3224

Publisher:

Frontiers Research Foundation

Funders:

[42] Schweizerischer Nationalfonds
[42] Schweizerischer Nationalfonds
[UNSPECIFIED] Swiss Cancer League
[UNSPECIFIED] Bern University Research Foundation
[UNSPECIFIED] San Salvatore Foundation

Language:

English

Submitter:

Philippe Krebs

Date Deposited:

24 Nov 2017 17:06

Last Modified:

23 Oct 2019 02:22

Publisher DOI:

10.3389/fimmu.2016.00682

PubMed ID:

28119694

Uncontrolled Keywords:

cancer, inflammation, tumor microenvironment, interleukin-33, therapy

BORIS DOI:

10.7892/boris.107316

URI:

https://boris.unibe.ch/id/eprint/107316

Actions (login required)

Edit item Edit item
Provide Feedback