Early seizures predict the development of epilepsy in children and adolescents with stroke.

Breitweg, Ina; Stülpnagel, Celina von; Pieper, Tom; Lidzba, Karen; Holthausen, Hans; Staudt, Martin; Kluger, Gerhard (2017). Early seizures predict the development of epilepsy in children and adolescents with stroke. European journal of paediatric neurology, 21(3), pp. 465-467. Elsevier 10.1016/j.ejpn.2016.12.007

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PURPOSE To identify risk factors for the development of epilepsy after pediatric stroke. METHODS Retrospective analysis of hospital charts of 93 children and adolescents with post-neonatal non-traumatic stroke and a minimum follow-up of two years. Seizures during the first 48 h after onset of stroke symptoms were defined as "early seizures"; when two or more seizures occurred after this period, the patient was classified as "epileptic". RESULTS Early seizures, young age at stroke and MRI evidence of cortical involvement were observed more frequently in the children who developed epilepsy. These factors were, however, significantly interrelated; a stepwise multiple regression analysis in 46/93 patients with complete datasets identified only the occurrence of early seizures as a significant risk factor: 15/19 (79%) children with early seizures developed epilepsy, as opposed to only 7/53 (13%) without early seizures. CONCLUSION Children with stroke who show seizures during the first 48 h after onset of stroke symptoms have a high risk to develop post-stroke epilepsy, whereas in children without early seizures, post-stroke epilepsy is rare.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine > Neuropaediatrics

UniBE Contributor:

Lidzba, Karen

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1090-3798

Publisher:

Elsevier

Language:

English

Submitter:

Karen Lidzba

Date Deposited:

20 Feb 2018 15:49

Last Modified:

20 Feb 2018 15:49

Publisher DOI:

10.1016/j.ejpn.2016.12.007

PubMed ID:

28041798

Uncontrolled Keywords:

Childhood stroke Early seizures Epilepsy Risk factors

URI:

https://boris.unibe.ch/id/eprint/107441

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