Mobility and shape adaptation of neutrophil in the microchannel flow.

Czerwinska, Justyna; Pumpurus, Lauris; Rieger, Michael; Uehlinger, Dominik; Nita, Izabela Magdalena; Blank, Fabian (2017). Mobility and shape adaptation of neutrophil in the microchannel flow. Journal of the mechanical behavior of biomedical materials, 69, pp. 294-300. Elsevier 10.1016/j.jmbbm.2017.01.011

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This paper presents motion of neutrophil in a confined environment. Many experimental and theoretical studies were performed to show mechanics and basic principles of the white blood cell motion. However, they were mostly performed on flat plates without boundaries. More realistic model of flow in the capillaries based on confinement, curvature and adequate dimensions is applied in our experiments. These conditions lead to cell motion with deformability and three-dimensional character of that movement. Neutrophils are important cells for human immune system. Their motion and attachment often influence several diseases and immune response. Hence, studies focus on that particular cell type. We have shown that deformability of the cell influences its velocity. Cells actively participate in the flow using the shear gradient to advance control motion. The observed neutrophil velocity was from 1 up to 100μm/s.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Pneumology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Mu50 > Forschungsgruppe Pneumologie (Erwachsene)
09 Interdisciplinary Units > Microscopy Imaging Center MIC
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DCR Services > Core Facility Live Cell Imaging (LCI)

UniBE Contributor:

Uehlinger, Dominik; Nita, Izabela Magdalena and Blank, Fabian

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1751-6161

Publisher:

Elsevier

Language:

English

Submitter:

Rahel Holderegger

Date Deposited:

14 Dec 2017 10:40

Last Modified:

29 Aug 2019 14:19

Publisher DOI:

10.1016/j.jmbbm.2017.01.011

PubMed ID:

28126696

BORIS DOI:

10.7892/boris.107457

URI:

https://boris.unibe.ch/id/eprint/107457

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