History of Bystander Effects Research 1905-present; What’s in a name?

Mothersill, Carmel; Rusin, Andrej; Fernandez-Palomo, Cristian; Seymour, Colin (2017). History of Bystander Effects Research 1905-present; What’s in a name? International journal of radiation biology, 94(8), pp. 696-707. Taylor & Francis 10.1080/09553002.2017.1398436

Full text not available from this repository. (Request a copy)

PURPOSE: This review, which arose from a Radiation Research Society History symposium, traces the history of 'bystander effects' or 'indirect effects'(also known as 'abscopal effects', 'clastogenic effects' and more recently 'the secretosome'). In 1905, Murphy first drew attention to effects caused by the injection of irradiated cells into animals. In the present day, bystander effects are seen as part of the secretosome, where they coordinate responses to stressors at the tissue, organism, and population level. The review considers the history and also the reasons why this process of information exchange/communication appears to have been discovered and forgotten several times. The review then considers the evolution of our understanding of the mechanisms and what relevance these effects may have in radiation protection and radiotherapy. CONCLUSIONS: The authors conclude that the phenomenon currently described as a 'bystander effect' has been described under a variety of different names since 1905. However recent advances in biology have made it possible to investigate mechanisms and potential impacts more fully. This has led to the current upsurge in research into this effect of radiation.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy > Topographical and Clinical Anatomy

UniBE Contributor:

Fernandez Palomo, Cristian Gabriel

ISSN:

0955-3002

Publisher:

Taylor & Francis

Language:

English

Submitter:

Cristian Gabriel Fernandez Palomo

Date Deposited:

24 Jan 2018 16:42

Last Modified:

26 Aug 2018 02:19

Publisher DOI:

10.1080/09553002.2017.1398436

PubMed ID:

29095061

URI:

https://boris.unibe.ch/id/eprint/107480

Actions (login required)

Edit item Edit item
Provide Feedback