Biological Factors Contributing to the Response to Cognitive Training in Mild Cognitive Impairment

Peter, Jessica; Schumacher, Lena V.; Landerer, Verena; Abdulkadir, Ahmed; Kaller, Christoph P.; Lahr, Jacob; Klöppel, Stefan (2018). Biological Factors Contributing to the Response to Cognitive Training in Mild Cognitive Impairment. Journal of Alzheimer's disease, 61(1), pp. 333-345. IOS Press 10.3233/JAD-170580

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In mild cognitive impairment (MCI), small benefits from cognitive training were observed for memory functions but there appears to be great variability in the response to treatment. Our study aimed to improve the characterization and selection of those participants who will benefit from cognitive intervention. We evaluated the predictive value of disease-specific biological factors for the outcome after cognitive training in MCI (n = 25) and also considered motivation of the participants. We compared the results of the cognitive intervention group with two independent control groups of MCI patients (local memory clinic, n = 20; ADNI cohort, n = 302). The primary outcome measure was episodic memory as measured by verbal delayed recall of a 10-word list. Episodic memory remained stable after treatment and slightly increased 6 months after the intervention. In contrast, in MCI patients who did not receive an intervention, episodic memory significantly decreased during the same time interval. A larger left entorhinal cortex predicted more improvement in episodic memory after treatment and so did higher levels of motivation. Adding disease-specific biological factors significantly improved the prediction of training-related change compared to a model based simply on age and baseline performance. Bootstrapping with resampling (n = 1000) verified the stability of our finding. Cognitive training might be particularly helpful in individuals with a bigger left entorhinal cortex as individuals who did not benefit from intervention showed 17% less volume in this area. When extended to alternative treatment options, stratification based on disease-specific biological factors is a useful step towards individualized medicine.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Geriatric Psychiatry and Psychotherapy

UniBE Contributor:

Peter, Jessica; Abdulkadir, Ahmed and Klöppel, Stefan

Subjects:

100 Philosophy > 150 Psychology
600 Technology > 610 Medicine & health

ISSN:

1387-2877

Publisher:

IOS Press

Language:

English

Submitter:

Jessica Peter

Date Deposited:

29 Dec 2017 16:23

Last Modified:

29 Dec 2017 16:23

Publisher DOI:

10.3233/JAD-170580

PubMed ID:

29154279

BORIS DOI:

10.7892/boris.107656

URI:

https://boris.unibe.ch/id/eprint/107656

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