MRI of cystic fibrosis lung manifestations: sequence evaluation and clinical outcome analysis.

Scholz, O; Denecke, T; Böttcher, J; Schwarz, C; Mentzel, H-J; Streitparth, F; Maurer, Martin; Pfeil, A; Huppertz, A; Mehl, A; Staab, D; Hamm, B; Renz, D M (2017). MRI of cystic fibrosis lung manifestations: sequence evaluation and clinical outcome analysis. Clinical radiology, 72(9), pp. 754-763. Elsevier Science 10.1016/j.crad.2017.03.017

[img] Text
MRI of cystic fibrosis lung manifestations sequence evaluation and clinical outcome analysis.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (557kB) | Request a copy

AIM To evaluate different magnetic resonance imaging (MRI) sequences for diagnosis of pulmonary manifestations of cystic fibrosis (CF) in comparison to chest computed tomography (CT), including an extended outcome analysis. MATERIALS AND METHODS Twenty-eight patients with CF (15 male, 13 female, mean age 30.5±9.4 years) underwent CT and MRI of the lung. MRI (1.5 T) included different T2- and T1-weighted sequences: breath-hold HASTE (half Fourier acquisition single shot turbo spin echo) and VIBE (volumetric interpolated breath-hold examination, before and after contrast medium administration) sequences and respiratory-triggered PROPELLER (periodically rotated overlapping parallel lines with enhanced reconstruction) sequences with and without fat signal suppression, and perfusion imaging. CT and MRI images were evaluated by the modified Helbich and the Eichinger scoring systems. The clinical follow-up analysis assessed pulmonary exacerbations within 24 months. RESULTS The highest concordance to CT was achieved for the PROPELLER sequences without fat signal suppression (concordance correlation coefficient CCC of the overall modified Helbich score 0.93 and of the overall Eichinger score 0.93). The other sequences had the following concordance: PROPELLER with fat signal suppression (CCCs 0.91 and 0.92), HASTE (CCCs 0.87 and 0.89), VIBE (CCCs 0.84 and 0.85) sequences. In the outcome analysis, the combined MRI analysis of all five sequences and a specific MRI protocol (PROPELLER without fast signal suppression, VIBE sequences, perfusion imaging) reached similar correlations to the number of pulmonary exacerbations as the CT examinations. CONCLUSION An optimum lung MRI protocol in patients with CF consists of PROPELLER sequences without fat signal suppression, VIBE sequences, and lung perfusion analysis to enable high diagnostic efficacy and outcome prediction.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology

UniBE Contributor:

Maurer, Martin


600 Technology > 610 Medicine & health




Elsevier Science




Nicole Rösch

Date Deposited:

23 Feb 2018 15:47

Last Modified:

05 Nov 2019 14:16

Publisher DOI:


PubMed ID:





Actions (login required)

Edit item Edit item
Provide Feedback