Novel magnetic resonance technique for functional imaging of cystic fibrosis lung disease.

Nyilas, Sylvia Meryl; Bauman, Grzegorz; Sommer, Gregor; Stranzinger, Enno; Pusterla, Orso; Frey, Urs Peter; Korten, Insa Christina Severine; Singer, Florian; Casaulta Aebischer, Carmen; Bieri, Oliver; Latzin, Philipp (2017). Novel magnetic resonance technique for functional imaging of cystic fibrosis lung disease. European respiratory journal, 50(6) European Respiratory Society 10.1183/13993003.01464-2017

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Lung function tests are commonly used to monitor lung disease in cystic fibrosis (CF). While practical, they cannot locate the exact origin of functional impairment. Contemporary magnetic resonance imaging (MRI) techniques provide information on the location of disease but the need for contrast agents constrains their repeated application. We examined the correlation between functional MRI, performed without administration of contrast agent, and lung clearance index (LCI) from nitrogen multiple-breath washout (N2-MBW).40 children with CF (median (range) age 12.0 (6-18) years) and 12 healthy age-matched controls underwent functional and structural MRI and lung function tests on the same day. Functional MRI provided semiquantitative measures of perfusion (RQ) and ventilation (RFV) impairment as percentages of affected lung volume. Morphological MRI was evaluated using CF-specific scores. LCI measured global ventilation inhomogeneity.MRI detected functional impairment in CF: RFV 19-38% and RQ 16-35%. RFV and RQ correlated strongly with LCI (r=0.76, p<0.0001 and r=0.85, p<0.0001, respectively), as did total morphology score (r=0.81, p<0.0001). All indices differed significantly between patients with CF and healthy controls (p<0.001).Noninvasive functional MRI is a promising method to detect and visualise perfusion and ventilation impairment in CF without the need for contrast agents.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR)
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Unit Childrens Hospital > Forschungsgruppe Pneumologie (Pädiatrie)

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Nyilas, Sylvia Meryl; Stranzinger, Enno; Frey, Urs Peter; Korten, Insa Christina Severine; Casaulta Aebischer, Carmen; Bieri, Oliver and Latzin, Philipp

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0903-1936

Publisher:

European Respiratory Society

Language:

English

Submitter:

Nicole Rösch

Date Deposited:

16 Jan 2018 13:07

Last Modified:

24 Oct 2019 15:35

Publisher DOI:

10.1183/13993003.01464-2017

PubMed ID:

29217601

BORIS DOI:

10.7892/boris.107777

URI:

https://boris.unibe.ch/id/eprint/107777

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