Hyperpolarized 129Xenon Magnetic Resonance Imaging to Quantify Regional Ventilation Differences in Mild to Moderate Asthma: A Prospective Comparison Between Semiautomated Ventilation Defect Percentage Calculation and Pulmonary Function Tests.

Ebner, Lukas; He, Mu; Virgincar, Rohan S; Heacock, Timothy; Kaushik, Suryanarayanan S; Freemann, Matthew S; McAdams, H Page; Kraft, Monica; Driehuys, Bastiaan (2017). Hyperpolarized 129Xenon Magnetic Resonance Imaging to Quantify Regional Ventilation Differences in Mild to Moderate Asthma: A Prospective Comparison Between Semiautomated Ventilation Defect Percentage Calculation and Pulmonary Function Tests. Investigative radiology, 52(2), pp. 120-127. Lippincott Williams & Wilkins 10.1097/RLI.0000000000000322

[img]
Preview
Text
Hyperpolarized 129Xenon magnetic Resonance Imaging to quantify regional ventilatioin differences in mild moderate asthma.pdf - Published Version
Available under License Publisher holds Copyright.

Download (1MB) | Preview

OBJECTIVES The aim of this study was to investigate ventilation in mild to moderate asthmatic patients and age-matched controls using hyperpolarized (HP) Xenon magnetic resonance imaging (MRI) and correlate findings with pulmonary function tests (PFTs). MATERIALS AND METHODS This single-center, Health Insurance Portability and Accountability Act-compliant prospective study was approved by our institutional review board. Thirty subjects (10 young asthmatic patients, 26 ± 6 years; 3 males, 7 females; 10 older asthmatic patients, 64 ± 6 years; 3 males, 7 females; 10 healthy controls) were enrolled. After repeated PFTs 1 week apart, the subjects underwent 2 MRI scans within 10 minutes, inhaling 1-L volumes containing 0.5 to 1 L of Xe. Xe ventilation signal was quantified by linear binning, from which the ventilation defect percentage (VDP) was derived. Differences in VDP among subgroups and variability with age were evaluated using 1-tailed t tests. Correlation of VDP with PFTs was tested using Pearson correlation coefficient. Reproducibility of VDP was assessed using Bland-Altman plots, linear regression (R), intraclass correlation coefficient, and concordance correlation coefficient. RESULTS Ventilation defect percentage was significantly higher in young asthmatic patients versus young healthy subjects (8.4% ± 3.2% vs 5.6% ± 1.7%, P = 0.031), but not in older asthmatic patients versus age-matched controls (16.8% ± 10.3% vs 11.6% ± 6.6%, P = 0.13). Ventilation defect percentage was found to increase significantly with age (healthy, P = 0.05; asthmatic patients, P = 0.033). Ventilation defect percentage was highly reproducible (R = 0.976; intraclass correlation coefficient, 0.977; concordance correlation coefficient, 0.976) and significantly correlated with FEV1% (r = -0.42, P = 0.025), FEF25%-75% (r = -0.45, P = 0.019), FEV1/FVC (r = -0.71, P < 0.0001), FeNO (r = 0.69, P < 0.0001), and RV/TLC (r = 0.51, P = 0.0067). Bland-Altman analysis showed a bias for VDP of -0.88 ± 1.52 (FEV1%, -0.33 ± 7.18). CONCLUSIONS Xenon MRI is able to depict airway obstructions in mild to moderate asthma and significantly correlates with PFTs.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology

UniBE Contributor:

Ebner, Lukas

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0020-9996

Publisher:

Lippincott Williams & Wilkins

Language:

English

Submitter:

Nicole Rösch

Date Deposited:

26 Feb 2018 16:01

Last Modified:

31 Mar 2018 02:30

Publisher DOI:

10.1097/RLI.0000000000000322

PubMed ID:

27662575

BORIS DOI:

10.7892/boris.107782

URI:

https://boris.unibe.ch/id/eprint/107782

Actions (login required)

Edit item Edit item
Provide Feedback