Real-world navigation in amnestic mild cognitive impairment: the relation to visuospatial memory and volume of hippocampal subregions

Peter, Jessica; Sandkamp, Richard; Minkova, Lora; Schumacher, Lena V.; Kaller, Christoph P.; Abdulkadir, Ahmed; Klöppel, Stefan (2018). Real-world navigation in amnestic mild cognitive impairment: the relation to visuospatial memory and volume of hippocampal subregions. Neuropsychologia, 109, pp. 86-94. Elsevier 10.1016/j.neuropsychologia.2017.12.014

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Spatial disorientation is a frequent symptom in Alzheimer's disease and in mild cognitive impairment (MCI). In the clinical routine, spatial orientation is less often tested with real-world navigation but rather with 2D visuoconstructive tasks. However, reports about the association between the two types of tasks are sparse. Additionally, spatial disorientation has been linked to volume of the right hippocampus but it remains unclear whether right hippocampal subregions have differential involvement in real-world navigation. Yet, this would help uncover different functional roles of the subregions, which would have important implications for understanding the neuronal underpinnings of navigation skills. We compared patients with amnestic MCI (aMCI; n=25) and healthy elderly controls (HC; n=25) in a real-world navigation task that engaged different spatial processes. The association between real-world navigation and different visuoconstructive tasks was tested (i.e., figures from the Consortium to Establish a Registry for Alzheimer's Disease; CERAD, the Rey-Osterrieth Complex Figure task; and clock drawing). Furthermore, the relation between spatial navigation and volume of right hippocampal subregions was examined. Linear regression and relative weight analysis were applied for statistical analyses. Patients with aMCI were significantly less able to correctly navigate through a route compared to HC but had comparable map drawing and landmark recognition skills. The association between visuoconstructive tasks and real-world navigation was only significant when using the visuospatial memory component of the Rey figure. In aMCI, more volume of the right hippocampal tail was significantly associated with better navigation skills, while volume of the right CA2/3 region was a significant predictor in HC. Standard visuoconstructive tasks (e.g., the CERAD figures or clock drawing) are not sufficient to detect real-world spatial disabilities in aMCI. Consequently, more complex visuoconstructive tasks (i.e., the Rey figure) should be routinely included in the assessment of cognitive functions in the context of AD. Moreover, in those elderly individuals with impaired complex visuospatial memory, route finding behaviour should be evaluated in detail. Regarding the contribution of hippocampal subregions to spatial navigation, the right hippocampal tail seems to be particularly important for patients with aMCI, while the CA2/3 region appears to be more relevant in HC.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Geriatric Psychiatry and Psychotherapy

UniBE Contributor:

Peter, Jessica; Abdulkadir, Ahmed and Klöppel, Stefan

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0028-3932

Publisher:

Elsevier

Language:

English

Submitter:

Jessica Peter

Date Deposited:

05 Apr 2018 14:42

Last Modified:

05 Apr 2018 15:59

Publisher DOI:

10.1016/j.neuropsychologia.2017.12.014

PubMed ID:

29237555

BORIS DOI:

10.7892/boris.107785

URI:

https://boris.unibe.ch/id/eprint/107785

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