Rinaldi, Andrea; Mian, Michael; Chigrinova, Ekaterina; Arcaini, Luca; Bhagat, Govind; Novak, Urban; Rancoita, Paola M. V.; De Campos, Cassio P.; Forconi, Francesco; Gascoyne, Randy D.; Facchetti, Fabio; Ponzoni, Maurilio; Govi, Silvia; Ferreri, Andrés J. M.; Mollejo, Manuela; Piris, Miguel A.; Baldini, Luca; Soulier, Jean; Thieblemont, Catherine; Canzonieri, Vincenzo; ... (2011). Genome-wide DNA profiling of marginal zone lymphomas identifies subtype-specific lesions with an impact on the clinical outcome. Blood, 117(5), pp. 1595-1604. Washington, D.C.: American Society of Hematology 10.1182/blood-2010-01-264275
Full text not available from this repository. (Request a copy)Marginal zone B-cell lymphomas (MZLs) have been divided into 3 distinct subtypes (extranodal MZLs of mucosa-associated lymphoid tissue [MALT] type, nodal MZLs, and splenic MZLs). Nevertheless, the relationship between the subtypes is still unclear. We performed a comprehensive analysis of genomic DNA copy number changes in a very large series of MZL cases with the aim of addressing this question. Samples from 218 MZL patients (25 nodal, 57 MALT, 134 splenic, and 2 not better specified MZLs) were analyzed with the Affymetrix Human Mapping 250K SNP arrays, and the data combined with matched gene expression in 33 of 218 cases. MALT lymphoma presented significantly more frequently gains at 3p, 6p, 18p, and del(6q23) (TNFAIP3/A20), whereas splenic MZLs was associated with del(7q31), del(8p). Nodal MZLs did not show statistically significant differences compared with MALT lymphoma while lacking the splenic MZLs-related 7q losses. Gains of 3q and 18q were common to all 3 subtypes. del(8p) was often present together with del(17p) (TP53). Although del(17p) did not determine a worse outcome and del(8p) was only of borderline significance, the presence of both deletions had a highly significant negative impact on the outcome of splenic MZLs.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology |
UniBE Contributor: |
Novak, Urban |
ISSN: |
0006-4971 |
Publisher: |
American Society of Hematology |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:09 |
Last Modified: |
05 Dec 2022 14:00 |
Publisher DOI: |
10.1182/blood-2010-01-264275 |
PubMed ID: |
21115979 |
Web of Science ID: |
000286925500026 |
URI: |
https://boris.unibe.ch/id/eprint/1078 (FactScience: 201825) |
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