[Molecular biology of malignant lymphomas for non-specialists]

Novak, Urban (2010). [Molecular biology of malignant lymphomas for non-specialists]. Therapeutische Umschau, 67(10), pp. 501-4. Bern: Huber

Full text not available from this repository.

Lymphomas comprise a variety of entities with remarkable clinical heterogeneity. This review summarizes the current knowledge on the pathogenesis of major mature B-cell lymphoma subtypes for clinicians working outside the field of hemato-oncology. The understanding of the pathogenesis of lymphomas is linked to the knowledge on normal B-cell differentiation. The clinical diversity is manifested in the different mechanisms involved in lymphomagenesis that include characteristic chromosomal translocations deregulating proto-oncogenes, and inactivation of tumor suppressor genes through deletions and mutations. Gene-expression profiling has dissected certain lymphomas into morphologically indistinguishable, but clinically important subgroups and uncovered pathways suitable for specific therapeutic interventions.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology

UniBE Contributor:

Novak, Urban

ISSN:

0040-5930

Publisher:

Huber

Language:

German

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:09

Last Modified:

05 Dec 2022 14:00

PubMed ID:

20886455

URI:

https://boris.unibe.ch/id/eprint/1079 (FactScience: 201826)

Actions (login required)

Edit item Edit item
Provide Feedback