RNA-mediated transgenerational inheritance in ciliates and plants.

Neeb, Zachary Thomas; Nowacki, Mariusz (2018). RNA-mediated transgenerational inheritance in ciliates and plants. Chromosoma, 127(1), pp. 19-27. Springer 10.1007/s00412-017-0655-4

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In the age of next-generation sequencing (NGS) and with the availability of whole sequenced genomes and epigenomes, some attention has shifted from purely sequence-based studies to those of heritable epigenetic modifications. Transgenerational inheritance can be defined as heritable changes to the state of DNA that may be passed on to subsequent generations without alterations to the underlying DNA sequence. Although this phenomenon has been extensively studied in many systems, studies of transgenerational inheritance in mammals and other higher-level eukaryotes may be complicated by the fact that many epigenetic marks are reprogrammed during sexual reproduction. This, by definition, may obscure our interpretation of what is in fact truly transgenerational. Therefore, in this mini review, we discuss what is currently known in the field about transgenerational epigenetic inheritance in ciliates and plants, with a particular emphasis on RNA-mediated processes and changes in chromatin states.

Item Type:

Journal Article (Review Article)

Division/Institute:

08 Faculty of Science > Department of Biology > Institute of Cell Biology > Ciliate
08 Faculty of Science > Department of Biology > Institute of Cell Biology

UniBE Contributor:

Neeb, Zachary Thomas and Nowacki, Mariusz

Subjects:

500 Science > 570 Life sciences; biology

ISSN:

0009-5915

Publisher:

Springer

Language:

English

Submitter:

Mariusz Nowacki

Date Deposited:

20 Apr 2018 12:55

Last Modified:

27 Oct 2019 21:15

Publisher DOI:

10.1007/s00412-017-0655-4

PubMed ID:

29230532

Uncontrolled Keywords:

Ciliates Epigenetics Non-Mendelian inheritance Plants Small RNA Transgenerational inheritance

BORIS DOI:

10.7892/boris.107903

URI:

https://boris.unibe.ch/id/eprint/107903

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