A mathematical model of low grade gliomas treated with temozolomide and its therapeutical implications.

Bogdańska, M U; Bodnar, M; Belmonte-Beitia, J; Murek, Michael; Schucht, Philippe; Beck, Jürgen; Pérez-García, V M (2017). A mathematical model of low grade gliomas treated with temozolomide and its therapeutical implications. Mathematical biosciences, 288, pp. 1-13. Elsevier 10.1016/j.mbs.2017.02.003

Text 1-s2.0-S0025556417300603-main.pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Download (1MB)

Low grade gliomas (LGGs) are infiltrative and incurable primary brain tumours with typically slow evolution. These tumours usually occur in young and otherwise healthy patients, bringing controversies in treatment planning since aggressive treatment may lead to undesirable side effects. Thus, for management decisions it would be valuable to obtain early estimates of LGG growth potential. Here we propose a simple mathematical model of LGG growth and its response to chemotherapy which allows the growth of LGGs to be described in real patients. The model predicts, and our clinical data confirms, that the speed of response to chemotherapy is related to tumour aggressiveness. Moreover, we provide a formula for the time to radiological progression, which can be possibly used as a measure of tumour aggressiveness. Finally, we suggest that the response to a few chemotherapy cycles upon diagnosis might be used to predict tumour growth and to guide therapeutical actions on the basis of the findings.

Interest & Impact

Downloads

1 since deposited on 27 Feb 2018
0 in the past 12 months

Citations

5 Citations in Web of Science ®
6 Citations in Scopus

Search

in Google Scholar™

Services

Actions (login required)

Edit item

Actions (login required)

Edit item