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Mario Nuvolone, Nicolas Schmid, Gino Miele, Silvia Sorce, Rita Moos, Christian Schori, Roger R. Beerli, Monika Bauer, Philippe Saudan, Klaus Dietmeier, Ingolf Lachmann, Michael Linnebank, Roland Martin, Ulf Kallweit, Veronika Kana, Elisabeth J. Rushing, Herbert Budka, Adriano Aguzzi
Cystatin F is a biomarker of prion pathogenesis in mice
www.plosone.org
www.plosone.org
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(The)Tj
1.7348 0 Td
(NRPE)Tj
2.6419 0 Td
(is)Tj
0.8164 0 Td
(in)Tj
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(charge)Tj
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(of)Tj
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(registration)Tj
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(encephalopathies)Tj
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(Switzerland.)Tj
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3.7304 0 Td
[(\n)12()22()11()2()]TJ
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[()11()12(\n)4()]TJ
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(p14-3-3)Tj
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(-80)Tj
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-34.4747 -1.2982 Td
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(Creutzfeldt-Jakob)Tj
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(certified)Tj
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(neuropathol-)Tj
-32.3317 -1.2983 Td
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4.1329 0 Td
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(guidelines)Tj
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(after)Tj
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(histopathological)Tj
6.9505 0 Td
(examination)Tj
5.1704 0 Td
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(the)Tj
1.4513 0 Td
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3.8835 0 Td
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(proteinase)Tj
4.3086 0 Td
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0.89 0 Td
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3.5263 0 Td
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ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 302.0031 529.8519 cm
BT
/F9 1 Tf
1 TL
-0.0133 Tc
0 0 Td
(sc)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 309.9401 525.3732 cm
BT
/F9 1 Tf
1 TL
-0.01 Tc
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(in)Tj
1.0261 0 Td
(brain)Tj
2.3187 0 Td
(homogenates)Tj
5.4652 0 Td
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(analysis.)Tj
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-29.7975 -1.2982 Td
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4.5524 0 Td
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1.0148 0 Td
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1.4513 0 Td
(NIA/AA)Tj
3.6453 0 Td
(criteria)Tj
3.0274 0 Td
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0.83 0.64 0.02 0 k
(7)Tj
0 g
(].)Tj
-35.5801 -1.2983 Td
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1.6044 0 Td
(all)Tj
1.1281 0 Td
(NRPE)Tj
2.6873 0 Td
(cases,)Tj
2.4094 0 Td
(date)Tj
1.8822 0 Td
(of)Tj
1.0035 0 Td
(CSF)Tj
1.865 0 Td
(draw,)Tj
2.4322 0 Td
(date)Tj
1.8821 0 Td
(of)Tj
1.0035 0 Td
(death)Tj
2.3981 0 Td
(and)Tj
1.7121 0 Td
(autopsy,)Tj
3.4979 0 Td
(histopathological)Tj
6.9562 0 Td
(report)Tj
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(and)Tj
-35.1322 -1.2982 Td
(p14-3-3)Tj
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(results)Tj
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3.8323 0 Td
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1.7121 0 Td
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3.0387 0 Td
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1.9729 0 Td
(insufficient)Tj
4.6601 0 Td
(CSF)Tj
1.8652 0 Td
(leftover)Tj
3.1861 0 Td
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(with)Tj
1.9729 0 Td
(macro-)Tj
-34.5596 -1.2982 Td
(scopically)Tj
4.0365 0 Td
(haemorrhagic)Tj
5.7203 0 Td
(CSF)Tj
1.8707 0 Td
(\(14)Tj
1.4967 0 Td
(DEF)Tj
2.0353 0 Td
(CJD)Tj
1.9275 0 Td
(and)Tj
1.7121 0 Td
(2)Tj
0.6917 0 Td
(Def)Tj
1.6497 0 Td
(AD\))Tj
1.9616 0 Td
(were)Tj
2.0976 0 Td
(excluded)Tj
3.736 0 Td
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2.1827 0 Td
(the)Tj
1.4513 0 Td
(study.)Tj
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-31.3735 -1.2983 Td
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(diagnostic)Tj
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(Alzheimer's)Tj
-32.5187 -1.3039 Td
(disease)Tj
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(AD,)Tj
1.8652 0 Td
(n)Tj
0.771 0 Td
(=)Tj
0.7994 0 Td
(26\))Tj
1.5137 0 Td
(and)Tj
1.729 0 Td
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2.2053 0 Td
(non-demented,)Tj
6.3893 0 Td
(control)Tj
3.1238 0 Td
(subjects)Tj
3.3788 0 Td
(\(Controls,)Tj
4.286 0 Td
(n)Tj
0.771 0 Td
(=)Tj
0.7994 0 Td
(24\))Tj
1.5137 0 Td
(were)Tj
-34.4463 -1.2983 Td
(obtained)Tj
3.7303 0 Td
(from)Tj
2.2054 0 Td
(the)Tj
1.474 0 Td
(biobank)Tj
3.4866 0 Td
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1.0147 0 Td
(the)Tj
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(of)Tj
1.0148 0 Td
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4.6828 0 Td
(University)Tj
4.405 0 Td
(Hospital)Tj
3.617 0 Td
(Zurich.)Tj
-30.9937 -1.2982 Td
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-0.01 Tc
1.7858 0 Td
(clinical)Tj
3.0274 0 Td
(history)Tj
2.965 0 Td
(of)Tj
1.0035 0 Td
(Alzheimer's)Tj
4.9038 0 Td
(disease)Tj
2.9763 0 Td
(cases)Tj
2.194 0 Td
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1.6838 0 Td
(extensively)Tj
4.5184 0 Td
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3.4242 0 Td
(and)Tj
1.7121 0 Td
(diagnosed)Tj
-31.3905 -1.304 Td
(according)Tj
4.1329 0 Td
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1.0147 0 Td
(strictly)Tj
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3.1123 0 Td
(diagnostic)Tj
4.2576 0 Td
(criteria.)Tj
3.2485 0 Td
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3.3619 0 Td
(underwent)Tj
4.5183 0 Td
(a)Tj
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0.7937 0 Td
(22\),)Tj
1.7121 0 Td
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3.0273 0 Td
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(\(n)Tj
1.0942 0 Td
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0.7937 0 Td
(24\),)Tj
1.7121 0 Td
(CSF)Tj
1.8709 0 Td
(testing)Tj
2.8403 0 Td
(\(all,)Tj
-35.9373 -1.2983 Td
(n)Tj
0.7596 0 Td
(=)Tj
0.7937 0 Td
(11)Tj
1.1622 0 Td
(with)Tj
1.9729 0 Td
(neurodegenerative)Tj
7.5571 0 Td
(markers)Tj
3.4525 0 Td
(such)Tj
2.041 0 Td
(as)Tj
0.9978 0 Td
(p-tau)Tj
2.3187 0 Td
(and)Tj
1.7121 0 Td
(amyloid)Tj
/F14 1 Tf
3.4356 0 Td
()Tj
/F9 1 Tf
(\).)Tj
1.2529 0 Td
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4.9606 0 Td
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(the)Tj
1.4513 0 Td
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1.6101 0 Td
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4.6035 0 Td
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1.9729 0 Td
(a)Tj
0.6462 0 Td
(diagnosis)Tj
3.9062 0 Td
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1.0034 0 Td
(AD.)Tj
1.8482 0 Td
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1.0942 0 Td
(three)Tj
2.2337 0 Td
(cases)Tj
2.194 0 Td
(the)Tj
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-34.4236 -1.2982 Td
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1.9728 0 Td
(a)Tj
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(dementia)Tj
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(neuro-)Tj
-34.6107 -1.2983 Td
(degenerative)Tj
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1.7688 0 Td
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2.5738 0 Td
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(clin)Tj
1.6837 0 Td
(AD)Tj
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1.4513 0 Td
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(AD)Tj
1.6328 0 Td
(and)Tj
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-27.2236 -1.2983 Td
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1.7858 0 Td
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(\(controls,)Tj
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0.7994 0 Td
(24\))Tj
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1.6951 0 Td
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1.0148 0 Td
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3.3676 0 Td
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1.9388 0 Td
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-34.5596 -1.2982 Td
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3.0784 0 Td
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3.6737 0 Td
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(ers)Tj
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(3.)Tj
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(Creutzfeldt-)Tj
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(Jakob)Tj
2.4944 0 Td
(disease)Tj
3.0161 0 Td
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1.1055 0 Td
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0.805 0 Td
(11\))Tj
1.508 0 Td
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1.0999 0 Td
(Alzheimer's)Tj
4.9718 0 Td
(disease)Tj
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(8\))Tj
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