Nationwide multicenter study on the management of pulmonary neuroendocrine (carcinoid) tumors.

Sadowski, Samira Mercedes; Christ, Emanuel; Bedat, Benoit; Kollár, Attila; Karenovics, Wolfram; Perren, Aurel; Triponez, Frederic (2018). Nationwide multicenter study on the management of pulmonary neuroendocrine (carcinoid) tumors. Endocrine Connections, 7(1), pp. 8-15. BioScientifica 10.1530/EC-17-0271

[img]
Preview
Text
8.full.pdf - Published Version
Available under License Creative Commons: Attribution-Noncommercial (CC-BY-NC).

Download (669kB) | Preview

Background/ Aim: To analyze the management and outcome of patients with primary typical (TC) and atypical lung carcinoids (AC) in Switzerland. METHODS Retrospective analysis of patients selected from a neuroendocrine tumor (NET) registry. Patients were divided into TC and AC according to pathology reports, and surgical procedures were grouped as wedge/ segmentectomy, lobectomy/ bi-lobectomy and pneumectomy. Survival analysis was performed using the Kaplan-Meier method and log-rank test. RESULTS Over 7 years, 113 pulmonary carcinoids (61.9% females, mean age 59.4 years) were included from 19 hospitals, with pathology data on Ki67 and necrosis incomplete in 16 cases. Eighty-three TC and 14 AC underwent surgical resection with a primary tumor size of median 14.5 range 1-80 mm and diagnosis was established in 55.8% at surgery. Mean follow-up was 30.2 23.1 months. Lobectomy was performed in 54.2% and wedge resection in 17.7% of cases. Six patients received additional systemic therapy. There was a trend for larger primary lesion size and a significantly higher rate of N2-N3 status in AC. Mean survival tended to be increased in patients with TC compared to AC (86.1 versus 48.4 months, p=0.06) and mean disease-free-interval after surgical resection was 74.1 and 48.3 months for TC and AC, respectively (p=0.74). CONCLUSION AC of the lung have a more malignant behavior and a trend to a worse outcome. The results of this registry reinforce the need for standardized histological diagnosis and inter-disciplinary therapeutic decision-making to improve the quality of care of patients with TC and AC.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition
04 Faculty of Medicine > Service Sector > Institute of Pathology
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology

UniBE Contributor:

Christ, Emanuel; Kollár, Attila and Perren, Aurel

Subjects:

600 Technology > 610 Medicine & health
500 Science > 570 Life sciences; biology

ISSN:

2049-3614

Publisher:

BioScientifica

Language:

English

Submitter:

Aurel Perren

Date Deposited:

20 Dec 2017 12:25

Last Modified:

25 Oct 2019 09:57

Publisher DOI:

10.1530/EC-17-0271

PubMed ID:

29229628

BORIS DOI:

10.7892/boris.108058

URI:

https://boris.unibe.ch/id/eprint/108058

Actions (login required)

Edit item Edit item
Provide Feedback