Are Inflammatory Cytokines Associated with Pain during Acute Myocardial Infarction?

Imholz, Laurin; Meister-Langraf, Rebecca E; Princip, Mary; Fux, Michaela; Schnyder, Ulrich; Barth, Jürgen; Znoj, Hans Jörg; Schmid, Jean-Paul; von Känel, Roland (2017). Are Inflammatory Cytokines Associated with Pain during Acute Myocardial Infarction? Neuroimmunomodulation, 24(3), pp. 154-161. Karger 10.1159/000481455

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OBJECTIVE

Pain and inflammation during acute myocardial infarction (AMI) have been associated with the development of posttraumatic stress disorder and may also impact negatively on somatic outcome. We investigated the relationship between pain during AMI and levels of circulating proinflammatory (tumor necrosis factor [TNF]-α, interleukin [IL]-6) and anti-inflammatory (IL-33 and tissue growth factor [TGF]-β1) cytokines.

METHODS

Data were collected as part of the Myocardial Infarction - Stress Prevention Intervention (MI-SPRINT) study. We included 140 patients (mean age 59.6 years, 82.1% male) with high acute psychological distress within 48 h after MI. Fasting blood samples were drawn thereafter to measure cytokine levels. Sociodemographic factors, psychological and medical data, as well as cardiometabolic markers were assessed with questionnaires and patient interviews.

RESULTS

Linear regression models showed a significant positive correlation of pain with TGF-β1 (b = 770.91, p = 0.031) and a significant inverse correlation of pain with IL-33 (b = -0.11, p = 0.015) after controlling for age, gender, body mass index, lifetime depression, acute stress disorder symptoms, and the prognostic Global Registry of Acute Coronary Events (GRACE) score. Pain was not associated with IL-6 but with the GRACE score (b = 0.01, p = 0.003). Pain showed no significant association with TNF-α.

CONCLUSION

Pain during MI was associated with anti- but not proinflammatory cytokines. As IL-33 has been shown to be cardioprotective, lower IL-33 levels with more intense pain may suggest a pathway through which increased pain during MI may have an impact on the medical prognosis.

Item Type:

 Journal Article (Original Article)

Division/Institute:

 04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology > Centre of Competence for Psychosomatic Medicine
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Institute of Clinical Chemistry
07 Faculty of Human Sciences > Institute of Psychology > Clinical Psychology and Psychotherapy
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology
07 Faculty of Human Sciences > Institute of Psychology

UniBE Contributor:

 Princip, Mary, Fux, Michaela, Znoj, Hans Jörg, von Känel, Roland

Subjects:

 100 Philosophy > 150 Psychology
600 Technology > 610 Medicine & health

ISSN:

 1021-7401

Publisher:

 Karger

Language:

 English

Submitter:

 Stefanie Hetzenecker

Date Deposited:

 09 Feb 2018 13:52

Last Modified:

 05 Dec 2022 15:08

Publisher DOI:

 10.1159/000481455

PubMed ID:

 29131079

Uncontrolled Keywords:

 Acute myocardial infarction Cardiovascular disease Cytokines Inflammation Pain Posttraumatic stress Psychological stress

BORIS DOI:

 10.7892/boris.108168

URI:

 https://boris.unibe.ch/id/eprint/108168

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