Psychological Stress, Inflammation, and Coronary Heart Disease.

Wirtz, Petra H; von Känel, Roland (2017). Psychological Stress, Inflammation, and Coronary Heart Disease. Current cardiology reports, 19(11), p. 111. Springer 10.1007/s11886-017-0919-x

[img] Text
10.1007%2Fs11886-017-0919-x.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (552kB) | Request a copy

PURPOSE OF REVIEW In this review, we summarize evidence on the risk factor psychological stress in the context of coronary heart disease (CHD) in humans and explore the role of inflammation as a potential underlying mechanism. RECENT FINDINGS While chronic stress increases the risk of incident CHD and poor cardiovascular prognosis, acute emotional stress can trigger acute CHD events in vulnerable patients. Evidence supporting a potential role for inflammation as a promising biological mechanism comes from population-based studies showing associations between chronic stress and increased inflammation. Similarly, experimental studies demonstrate acute stress-induced increases in inflammatory markers and suggest modulatory potential for pharmacological and biobehavioral interventions. So far, studies investigating patients with cardiovascular disease are few and the full sequence of events from stress to inflammation to CHD remains to be established. Psychological stress is an independent CHD risk factor associated with increased inflammation. Although promising, causality needs to be further explored.

Item Type:

Journal Article (Review Article)


04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology > Centre of Competence for Psychosomatic Medicine

UniBE Contributor:

von Känel, Roland








Stefanie Hetzenecker

Date Deposited:

27 Feb 2018 13:50

Last Modified:

25 Oct 2019 06:51

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

C-reactive protein Coronary heart disease Cytokines Exhaustion Inflammation Inflammatory stress response Interleukin Intervention Job burnout Psychosocial stress




Actions (login required)

Edit item Edit item
Provide Feedback