In human non-REM sleep, more slow-wave activity leads to less blood flow in the prefrontal cortex.

Tüshaus, Laura; Omlin, Ximena; Tuura, Ruth O'Gorman; Federspiel, Andrea; Luechinger, Roger; Staempfli, Philipp; König, Thomas; Achermann, Peter (2017). In human non-REM sleep, more slow-wave activity leads to less blood flow in the prefrontal cortex. Scientific Reports, 7(1), p. 14993. Nature Publishing Group 10.1038/s41598-017-12890-7

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Cerebral blood flow (CBF) is related to integrated neuronal activity of the brain whereas EEG provides a more direct measurement of transient neuronal activity. Therefore, we addressed what happens in the brain during sleep, combining CBF and EEG recordings. The dynamic relationship of CBF with slow-wave activity (SWA; EEG sleep intensity marker) corroborated vigilance state specific (i.e., wake, non-rapid eye movement (NREM) sleep stages N1-N3, wake after sleep) differences of CBF e.g. in the posterior cingulate, basal ganglia, and thalamus, indicating their role in sleep-wake regulation and/or sleep processes. These newly observed dynamic correlations of CBF with SWA - namely a temporal relationship during continuous NREM sleep in individuals - additionally implicate an impact of sleep intensity on the brain's metabolism. Furthermore, we propose that some of the aforementioned brain areas that also have been shown to be affected in disorders of consciousness might therefore contribute to the emergence of consciousness.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center

UniBE Contributor:

Federspiel, Andrea and König, Thomas

Subjects:

500 Science > 570 Life sciences; biology

ISSN:

2045-2322

Publisher:

Nature Publishing Group

Language:

English

Submitter:

Thomas König

Date Deposited:

29 Dec 2017 13:39

Last Modified:

31 Dec 2017 02:19

Publisher DOI:

10.1038/s41598-017-12890-7

PubMed ID:

29101338

BORIS DOI:

10.7892/boris.108245

URI:

https://boris.unibe.ch/id/eprint/108245

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